Associate Professor, Health and Kinesiology
Office#: 127 Human Clinical Research Facility
Mail Stop: 1542
Office Phone: (979) 220-2282
Other Title: Co-director & Head Clinical Research CTRAL
Primary Emphasis Area: Kinesiology
Vita: View Document
Google Scholar: Google Scholar Profile
Short Bio
Experience : Dr. Marielle Engelen, PhD, Associate Professor, currently serves as Co-Director and Head of Clinical Research for the Center for Translational Research in Aging and Longevity (CTRAL). She is an expert in the field of clinical nutrition and metabolism in relation to functional performance during aging and in chronic (wasting) diseases. Her research focuses on the metabolic alterations underlying muscle wasting and dysfunction (weakness/fatigue) in chronic diseases, involving the use of stable isotope methodologies, and the effects of nutritional intervention and exercise rehabilitation to restore metabolism and physical and cognitive performance in these patients. As such, she has conducted and supervised many acute studies and coordinating human clinical trials, examining the effects of protein and amino acid intervention in relation to aging and in patients with chronic wasting diseases (i.e., chronic obstructive pulmonary disease, cancer, cystic fibrosis, chronic heart failure, obstructive sleep apnea, cognitive impairment). In addition, she has the expertise in methodology and techniques to examine body composition, muscle function, physical performance, gut and cognitive function, balance, physical activity, wellbeing and clinical outcomes. She is the section editor "Translational Research in Wasting Disease" of the Current Opinion in Clinical Nutrition and Metabolism, and Associate editor for Clinical Nutrition-ESPEN. Education: Dr. Engelen studied Health Sciences (Movement Sciences) at Maastricht University, Maastricht, the Netherlands. In 1994, she worked as Research Associate at the Dept. of Respiratory and Critical Care Medicine at Harbor UCLA Medical Center, Torrance, CA. After she returned to the Netherlands, she worked as a PhD student at the Dept. of Respiratory Medicine at the Academic Hospital Maastricht and obtained her PhD in 2000 (title thesis: "Muscle wasting in COPD: a metabolic and functional perspective"), and subsequently worked as a postdoctoral fellow at the Dept of Surgery. From 2006 to 2012, she worked as Assistant/ Associate Professor at the Department of Geriatrics, University Arkansas for Medical Sciences and Arkansas Children's Hospital. Learn more about Dr. Engelen by visiting her page on CTRAL's website
Research Interests
chronic diseases and aging
clinical outcome
muscle-, cognitive- and gut function
protein and amino acid metabolism
stable isotopes
Publications (journal articles, books, book chapters)*

1. Mason A, Engelen M.P.K.J., Ivanov I, Toffolo G.M., Deutz N.E.P. A Four Compartments Compartmental Model to Assess Net Whole Body Protein Breakdown Using a Pulse of Phenylalanine and Tyrosine Stable Isotopes in Humans. Am J Physiol 2017: 313:E63-74

2. Kumar A., Davuluri G., Nascimento R., Engelen M.P.K.J. , Ten Have G.A.M., Deutz N.E.P., Dasarathy S. Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis. Hepatology 2017: 65:2045-58

3. Ten Have G.A.M., Deutz R.C.I., Engelen M.P.K.J., Wolfe R.R., Deutz N.E.P. Characteristics of a Pseudomonas aeruginosa induced porcine sepsis model for multi-organ metabolic flux measurements. Laboratory animals 2017:23677217718003. Epub 2017/07/07. doi: 10.1177/0023677217718003. PubMed PMID: 28679339.

4. Walker D.K., Thaden J.J., Wierzchowska - McNew A., Engelen M.P.K.J., Deutz N.E.P. Determination of beta-Hydroxy-beta-methylbutyrate Concentration and Enrichment in Human Plasma Using Chemical Ionization Gas Chromatography Tandem Mass Spectrometry. Journal of Chromatography B. 2017;1040:233-238

5. Jonker R., Deutz N.E.P., Erbland M.L., Anderson P.J., Engelen M.P.K.J. Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults. Metabolism 2017: 69:120-129

6. De Betue C.T.I., Garcia Casal X.C., van Waardenburg D.A., Schexnayder S.M., Joosten K.F.M., Deutz N.E.P., Engelen M.P.K.J. 24-Hour protein, arginine and citrulline metabolism in fed critically ill children - a stable isotope tracer study. Clinical Nutrition. 2017: 36:876-887

7. Ten Have G.A.M., Engelen M.P.K.J., Wolfe R.R., Deutz N.E.P. Phenylalanine isotope pulse method to measure effect of sepsis on protein breakdown and membrane transport in the pig. Am J Physiol 2017: 312:E519-529

8. Engelen M.P.K.J., Klimberg V.S., Allasia A, Deutz N.E.P. Presence of early stage cancer does not impair the early protein metabolic response to major surgery. Journal of Cachexia, Sarcopenia and Muscle. 2017: 8:447-456

9. Deutz N.E.P., Simbo S.Y., Ligthart-Melis G.C., Cynober C., Smriga N., Engelen M.P.K.J. Tolerance to increased supplemented dietary intake levels of methionine in healthy older adults. American Journal Clinical Nutrition 2017: 106:675-683

10. Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease. Am J Clin Nutr. 2016. doi: 10.3945/ajcn.115.125187. PubMed PMID: 27146652

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* Publication was joint-authored with students
Diss Publication was from a dissertation
ROS Publication was from a record of study

College of Education and Human Development Grants and Contracts (Current)

Nutritional Modulation to Minimize Resistance Exercise Induced Metabolic Deregulations and Improve Training Responsiveness in Chronic Obstructive Pulmonary Disease. (PI)
NIH-National Heart, Lung, and Blood Institute (Federal)
2019/09/15 - 2020/08/31
Total Funding: 756,559.

A longitudinal investigation of the cerebellum in adulthood: anatomical and network changes, motor function, and cognition. (Co-I)
DHHS-PHS-NIH (Federal)
2019/07/01 - 2024/06/30
Total Funding: 117,441.
Editorial Positions

Editor (2018 - ). Current Opinion Clinical Nutrition Metabolic Care

Assoc Editor (2017 - ). Clinical Nutrition

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