Photo of MARIELLE ENGELEN
MARIELLE ENGELEN
Associate Professor, Health and Kinesiology
Office#: 127 Human Clinical Research Facility
Mail Stop: 1542
Office Phone: (979) 220-2282
E-mail:
Other Title: Co-director & Head Clinical Research CTRAL
Primary Emphasis Area: Kinesiology
Vita: View Document
Google Scholar: Google Scholar Profile
Short Bio
Experience : Dr. Marielle Engelen, PhD, Associate Professor, currently serves as Co-Director and Head of Clinical Research for the Center for Translational Research in Aging and Longevity (CTRAL). She is an expert in the field of clinical nutrition and metabolism in relation to functional performance during aging and in chronic (wasting) diseases. Her research focuses on the metabolic alterations underlying muscle wasting and dysfunction (weakness/fatigue) in chronic diseases, involving the use of stable isotope methodologies, and the effects of nutritional intervention and exercise rehabilitation to restore metabolism and physical and cognitive performance in these patients. As such, she has conducted and supervised many acute studies and coordinating human clinical trials, examining the effects of protein and amino acid intervention in relation to aging and in patients with chronic wasting diseases (i.e., chronic obstructive pulmonary disease, cancer, cystic fibrosis, chronic heart failure, obstructive sleep apnea, cognitive impairment). In addition, she has the expertise in methodology and techniques to examine body composition, muscle function, physical performance, gut and cognitive function, balance, physical activity, wellbeing and clinical outcomes. She is the section editor "Translational Research in Wasting Disease" of the Current Opinion in Clinical Nutrition and Metabolism, and Associate editor for Clinical Nutrition-ESPEN. Education: Dr. Engelen studied Health Sciences (Movement Sciences) at Maastricht University, Maastricht, the Netherlands. In 1994, she worked as Research Associate at the Dept. of Respiratory and Critical Care Medicine at Harbor UCLA Medical Center, Torrance, CA. After she returned to the Netherlands, she worked as a PhD student at the Dept. of Respiratory Medicine at the Academic Hospital Maastricht and obtained her PhD in 2000 (title thesis: "Muscle wasting in COPD: a metabolic and functional perspective"), and subsequently worked as a postdoctoral fellow at the Dept of Surgery. From 2006 to 2012, she worked as Assistant/ Associate Professor at the Department of Geriatrics, University Arkansas for Medical Sciences and Arkansas Children's Hospital. Learn more about Dr. Engelen by visiting her page on CTRAL's website
Research Interests
chronic diseases and aging
clinical outcome
exercise
muscle-, cognitive- and gut function
nutrition
protein and amino acid metabolism
stable isotopes
Publications (journal articles, books, book chapters)*

1. Van der Meij B.S., Teleni L, Engelen M.P.K.J., Deutz N.E.P. Amino Acid Kinetics and the Response to Nutrition in Patients with Cancer. International Journal of Radiation Biology 2019: 95 (4):480-492

2. Engelen M.P.K.J., Pichard C. Editorial: Crosstalk between organs and multimodal therapeutic approaches: new insights. Current Opinion in Clinical Nutrition & Metabolic Care. 2019: 22(3): 183-184

3. Van der Meij B.S., Deutz N.E.P., Rodriguez R., Engelen M.P.K.J. Increased amino acid turnover and myofibrillar protein breakdown in advanced cancer are associated with muscle weakness and impaired physical function. Clinical Nutrition 2019

4. Ten Have G.A.M., Engelen M.P.K.J., Wolfe R.R., Deutz N.E.P. Inhibition of jejunal protein synthesis and breakdown in Pseudomonas aeruginosa induced sepsis pig model. American Journal Physiology 2019: 316 (6): G755-G762

5. Engelen M.P.K.J., Ten Have G.A.M., Thaden J.J., Deutz N.E.P. New advances in stable isotope dilution methods to assess whole body protein and amino acid metabolism. Current Opinion in Clinical Nutrition & Metabolic Care. 2019: 22(5): 337-346

6. Jonker R, Deutz N.E.P., Ligthart-Melis G.C., Zachria A.J., Veley E.A., Harrykissoon R., Engelen M.P.K.J. Preserved anabolic threshold and capacity as estimated by a novel stable tracer approach suggests no anabolic resistance or increased requirements in weight stable COPD patients. Clinical Nutrition 2019: 38 (4) 1833-1843

7. Jonker R., Deutz N.E.P., Schols A.M.W.J., Veley E.A., Harrykissoon R., Zachria A.J., Engelen M.P.K.J. Whole body protein anabolism in COPD patients and healthy older adults is not enhanced by adding either carbohydrates or leucine to a serving of protein. Clinical Nutrition 2019: 38 (4): 1684-1691

8. Mason A, Engelen M.P.K.J., Ivanov I, Toffolo G.M., Deutz N.E.P. A Four Compartments Compartmental Model to Assess Net Whole Body Protein Breakdown Using a Pulse of Phenylalanine and Tyrosine Stable Isotopes in Humans. Am J Physiol 2017: 313:E63-74

9. Kumar A., Davuluri G., Nascimento R., Engelen M.P.K.J. , Ten Have G.A.M., Deutz N.E.P., Dasarathy S. Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis. Hepatology 2017: 65:2045-58

10. Ten Have G.A.M., Deutz R.C.I., Engelen M.P.K.J., Wolfe R.R., Deutz N.E.P. Characteristics of a Pseudomonas aeruginosa induced porcine sepsis model for multi-organ metabolic flux measurements. Laboratory animals 2017:23677217718003. Epub 2017/07/07. doi: 10.1177/0023677217718003. PubMed PMID: 28679339.

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* Publication was joint-authored with students
Diss Publication was from a dissertation
ROS Publication was from a record of study

College of Education and Human Development Grants and Contracts (Current)

Nutritional Modulation to Minimize Resistance Exercise Induced Metabolic Deregulations and Improve Training Responsiveness in Chronic Obstructive Pulmonary Disease. (PI)
NIH-National Heart, Lung, and Blood Institute (Federal)
2019/09/15 - 2020/08/31
Total Funding: 756,559.

A longitudinal investigation of the cerebellum in adulthood: anatomical and network changes, motor function, and cognition. (Co-I)
DHHS-PHS-NIH (Federal)
2019/07/01 - 2024/06/30
Total Funding: 117,441.
Editorial Positions

Editor (2018 - ). Current Opinion Clinical Nutrition Metabolic Care

Associate Editor (2017 - ). Clinical Nutrition

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