Associate Professor, Health and Kinesiology
Office#: 127 Human Clinical Research Facility
Mail Stop: 1542
Office Phone: (979) 220-2282
Other Title: Co-director CTRAL
Primary Emphasis Area: Kinesiology
Vita: View Document
Google Scholar: Google Scholar Profile
Short Bio
Experience : Dr. Marielle Engelen, PhD, Associate Professor, currently serves as CoDirector and Head of Clinical Research for the Center for Translational Research in Aging and Longevity (CTRAL). She is an expert in the field of nutrition and metabolism in chronic diseases. Her research focuses on the metabolic alterations underlying involuntary weight loss and muscle wasting in chronic inflammatory diseases, involving the use of stable isotope methodologies, and the effects of dietary modulation and exercise intervention to restore metabolism and physical performance in these patients. As such, she has conducted and supervised many acute studies and coordinating human clinical trials, examining the effects of protein and amino acid intervention in healthy elderly and in those with chronic wasting diseases (i.e., chronic obstructive pulmonary disease, cancer, cystic fibrosis, chronic heart failure, obstructive sleep apnea, cognitive impairment). In addition, she has the expertise in methodology and techniques to examine body composition, muscle function, physical performance, gut and cognitive function, and wellbeing. Education: Dr. Engelen studied Health Sciences (Movement Sciences) at Maastricht University, Maastricht, the Netherlands. In 1994, she worked as Research Associate at the Dept. of Respiratory and Critical Care Medicine at Harbor UCLA Medical Center, Torrance, CA (director: Karlman Wasserman, MD, PhD). After she returned to the Netherlands, she worked as a PhD student at the Dept. of Respiratory Medicine at the Academic Hospital Maastricht and obtained her PhD in 2000 (title thesis: "Muscle wasting in COPD: a metabolic and functional perspective"), and subsequently worked as a postdoctoral fellow at the Dept of Surgery. Learn more about Dr. Engelen by visiting her page on CTRAL's website
Research Interests
chronic diseases and aging
stable isotopes
Publications (journal articles, books, book chapters)*

1. Mason A, Engelen M.P.K.J., Ivanov I, Toffolo G.M., Deutz N.E.P. A Four Compartments Compartmental Model to Assess Net Whole Body Protein Breakdown Using a Pulse of Phenylalanine and Tyrosine Stable Isotopes in Humans. Am J Physiol 2017: 313:E63-74

2. Kumar A., Davuluri G., Nascimento R., Engelen M.P.K.J. , Ten Have G.A.M., Deutz N.E.P., Dasarathy S. Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis. Hepatology 2017: 65:2045-58

3. Ten Have G.A.M., Deutz R.C.I., Engelen M.P.K.J., Wolfe R.R., Deutz N.E.P. Characteristics of a Pseudomonas aeruginosa induced porcine sepsis model for multi-organ metabolic flux measurements. Laboratory animals 2017:23677217718003. Epub 2017/07/07. doi: 10.1177/0023677217718003. PubMed PMID: 28679339.

4. Walker D.K., Thaden J.J., Wierzchowska - McNew A., Engelen M.P.K.J., Deutz N.E.P. Determination of beta-Hydroxy-beta-methylbutyrate Concentration and Enrichment in Human Plasma Using Chemical Ionization Gas Chromatography Tandem Mass Spectrometry. Journal of Chromatography B. 2017;1040:233-238

5. Jonker R., Deutz N.E.P., Erbland M.L., Anderson P.J., Engelen M.P.K.J. Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults. Metabolism 2017: 69:120-129

6. De Betue C.T.I., Garcia Casal X.C., van Waardenburg D.A., Schexnayder S.M., Joosten K.F.M., Deutz N.E.P., Engelen M.P.K.J. 24-Hour protein, arginine and citrulline metabolism in fed critically ill children - a stable isotope tracer study. Clinical Nutrition. 2017: 36:876-887

7. Ten Have G.A.M., Engelen M.P.K.J., Wolfe R.R., Deutz N.E.P. Phenylalanine isotope pulse method to measure effect of sepsis on protein breakdown and membrane transport in the pig. Am J Physiol 2017: 312:E519-529

8. Engelen M.P.K.J., Klimberg V.S., Allasia A, Deutz N.E.P. Presence of early stage cancer does not impair the early protein metabolic response to major surgery. Journal of Cachexia, Sarcopenia and Muscle. 2017: 8:447-456

9. Deutz N.E.P., Simbo S.Y., Ligthart-Melis G.C., Cynober C., Smriga N., Engelen M.P.K.J. Tolerance to increased supplemented dietary intake levels of methionine in healthy older adults. American Journal Clinical Nutrition 2017: 106:675-683

10. Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease. Am J Clin Nutr. 2016. doi: 10.3945/ajcn.115.125187. PubMed PMID: 27146652

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* Publication was joint-authored with students
Diss Publication was from a dissertation
ROS Publication was from a record of study

College of Education and Human Development Grants and Contracts (Current)

IBM Sensor Testing. (Co-PI)
International Business Machines (IBM) (Private)
2018/06/07 - 2018/12/07
Total Funding: 20,256.

Effects of Low Fose of Fish Oil (EPA+DHA) vs. combined EPA+DHA and HMB or Curcumin Supplementation on Protein Metabolism, Muscle Mass and Functional Capacity in Moderate to Severe COPD. (Co-PI)
Abbott Nutrition (Private)
2018/03/21 - 2019/12/04
Total Funding: 337,496.

Role of Metabolic Phenotyping, Changes in Gut Function and the Response to a Meal to Explain the Variability in Weight Loss induced by Very Low Caloric Diet in (Morbidly) Obese Adults. (PI)
European Society for Clinical Nutrition and Metabolism (Private)
2017/09/01 - 2019/08/31
Total Funding: 57,880.
Editorial Positions

Assoc Editor (2017 - ). Clinical Nutrition

HLKN Faculty   |   HLKN Staff