Director Center for Translational Research Aging, Health and Kinesiology
Office#: Human Clinical Research Facility
Mail Stop: 4253
Office Phone: (979) 220-2910
Directory Title: Director Center for Translational Research Aging
Primary Emphasis Area: Kinesiology
Vita: View Document
Google Scholar: Google Scholar Profile
Short Bio
Experience : Dr. Nicolaas Deutz, MD, PhD currently serves as Director for the Center for Translational Research in Aging and Longevity (CTRAL). For more than 30 years, his research background and expertise focus on nutrition, metabolism, and physiology studies involving the use of stable isotope methodologies, both in humans and animals. Dr. Deutz has extensive experience with isotopic calculations, validation and data interpretation. The stable isotope approaches are used in several studies to unravel the metabolic changes in patients with chronic diseases (i.e., chronic obstructive pulmonary disease, cancer, cystic fibrosis, chronic heart failure, obstructive sleep apnea, mild cognitive impairment and dementia, autism spectrum disorder). This research leads to new insights in protein and amino acid kinetics in subjects with chronic disease and resulted in specific recommendations to nutritional supplements as method for reducing muscle wasting. Recently, he started studying the anabolic effects of specialized nutritional supplements in different chronic diseases and models of disease. Using translational approaches is a logical extension of the body of his research in the field of protein and amino acids metabolism. Education: Dr. Deutz obtained his MD and PhD at the University of Amsterdam, Netherlands. He is a medical physiologist and Nutrition Physician Specialist. Learn more about Dr. Deutz by visiting his page on CTRAL's website
Research Interests
amino acids
chroninc disease
clinical nutrition
older adults
Publications (journal articles, books, book chapters)*

1. de Betue CTI, Garcia Casal XC, van Waardenburg DA, Schexnayder SM, Joosten KFM, Deutz NEP, Engelen M. 24-Hour protein, arginine and citrulline metabolism in fed critically ill children - A stable isotope tracer study. Clin Nutr. 2017;36(3):876-87. Epub 2017/01/17. doi: 10.1016/j.clnu.2016.12.023. PubMed PMID: 28089618; PMCID: PMC5404980.

2. Mason A, Engelen M, Ivanov I, Toffolo GM, Deutz NEP. A four-compartment compartmental model to assess net whole body protein breakdown using a pulse of phenylalanine and tyrosine stable isotopes in humans. American journal of physiology Endocrinology and metabolism. 2017;313(1):E63-E74. Epub 2017/03/09. doi: 10.1152/ajpendo.00362.2016. PubMed PMID: 28270442.

3. Barazzoni R, Deutz NEP, Biolo G, Bischoff S, Boirie Y, Cederholm T, Cuerda C, Delzenne N, Leon Sanz M, Ljungqvist O, Muscaritoli M, Pichard C, Preiser JC, Sbraccia P, Singer P, Tappy L, Thorens B, Van Gossum A, Vettor R, Calder PC. Carbohydrates and insulin resistance in clinical nutrition: Recommendations from the ESPEN expert group. Clin Nutr. 2017;36(2):355-63. Epub 2016/10/01. doi: 10.1016/j.clnu.2016.09.010. PubMed PMID: 27686693.

4. Kumar A, Davuluri G, Silva RNE, Engelen M, Ten Have GAM, Prayson R, Deutz NEP, Dasarathy S. Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis. Hepatology. 2017;65(6):2045-58. Epub 2017/02/15. doi: 10.1002/hep.29107. PubMed PMID: 28195332; PMCID: PMC5444955.

5. Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults. Metabolism: clinical and experimental. 2017;69:120-9. Epub 2017/03/14. doi: 10.1016/j.metabol.2016.12.010. PubMed PMID: 28285641; PMCID: PMC5351771.

6. Standley RA, Distefano G, Pereira SL, Tian M, Kelly OJ, Coen PM, Deutz NEP, Wolfe RR, Goodpaster BH. Effects of beta-hydroxy-beta-methylbutyrate on skeletal muscle mitochondrial content and dynamics, and lipids after 10 days of bed rest in older adults. J Appl Physiol (1985). 2017;123(5):1092-100. Epub 2017/07/15. doi: 10.1152/japplphysiol.00192.2017. PubMed PMID: 28705993.

7. Arends J, Baracos V, Bertz H, Bozzetti F, Calder PC, Deutz NEP, Erickson N, Laviano A, Lisanti MP, Lobo DN, McMillan DC, Muscaritoli M, Ockenga J, Pirlich M, Strasser F, de van der Schueren M, Van Gossum A, Vaupel P, Weimann A. ESPEN expert group recommendations for action against cancer-related malnutrition. Clin Nutr. 2017;36(5):1187-96. Epub 2017/07/12. doi: 10.1016/j.clnu.2017.06.017. PubMed PMID: 28689670.

8. Walker DK, Thaden JJ, Wierzchowska-McNew A, Engelen M, Deutz NEP. Determination of beta-hydroxy-beta-methylbutyrate concentration and enrichment in human plasma using chemical ionization gas chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1040:233-8. Epub 2016/11/20. doi: 10.1016/j.jchromb.2016.11.010. PubMed PMID: 27856194; PMCID: PMC5191936.

9. Ten Have GAM, Engelen M, Wolfe RR, Deutz NEP. Phenylalanine isotope pulse method to measure effect of sepsis on protein breakdown and membrane transport in the pig. American journal of physiology Endocrinology and metabolism. 2017;312(6):E519-E29. Epub 2017/03/16. doi: 10.1152/ajpendo.00351.2016. PubMed PMID: 28292760; PMCID: PMC5494580.

10. Hakvoort, T., He, Y., Kulik, W., Vermeulen, J. L., Duijst, S., Ruijter, J. M., Runge, JH, Deutz, N.E.P., Koehler, S.E., Lamers, W. H. (2017). Pivotal role of glutamine synthetase in ammonia detoxification. Hepatology, 65(1), 281-293

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* Publication was joint-authored with students
Diss Publication was from a dissertation
ROS Publication was from a record of study

College of Education and Human Development Grants and Contracts (Current)

Effects of Low Fose of Fish Oil (EPA+DHA) vs. combined EPA+DHA and HMB or Curcumin Supplementation on Protein Metabolism, Muscle Mass and Functional Capacity in Moderate to Severe COPD. (PI)
Abbott Nutrition (Private)
2018/03/21 - 2019/12/04
Total Funding: 337,496.

Catapult Round 4 Center - CTRAL Clinical Research Symposium ($5,000). (PI)
TAMU College of Education & Human Development (State)
2018/01/15 - 2019/06/15
Total Funding: 0.

Role of Metabolic Phenotyping, Changes in Gut Function and the Response to a Meal to Explain the Variability in Weight Loss induced by Very Low Caloric Diet in (Morbidly) Obese Adults. (Co-PI)
European Society for Clinical Nutrition and Metabolism (Private)
2017/09/01 - 2019/08/31
Total Funding: 57,880.

Engineering Research Center for Precise Advanced Technologies andHealth Systems for Underserved Populations (PATHS-UP). (Co-PI)
National Science Foundation (Federal)
2017/08/01 - 2022/07/31
Total Funding: 28,545.

Nutrition and Exercise in Critical Illness (The NEXIS Trial): A Randomized Trail of Combined Cycle Ergometry and Amino Acids in the ICU. (PI)
University of Vermont - NIH (Federal)
2017/04/01 - 2022/03/31
Total Funding: 112,697.

Integrated Health Sciences Core. (PI)
Texas A&M Agrilife Research-National Institutes of Health (Federal)
2014/04/01 - 2019/03/31
Total Funding: 92,140.
Courses Taught
2012 - 2013
KINE 685
Editorial Positions

Assoc Editor (2014 - ). Clinical Nutrition Experimental

Editorial Board Member (2008 - ). American Journal of Physiology: Endocrinology and Metabolism

Editor (2005 - ). Clinical Nutrition

Editor (2005 - ). e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism;


(2013-2013). ESPEN Followship.  Effect of enteral nutritional intervention on glutathione metabolism during Pseudomonas aeruginosa induced sepsis in the pig

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