Photo of NICOLAAS DEUTZ
NICOLAAS DEUTZ
Director Center for Translational Research Aging, Health and Kinesiology
Office#: 125 Human Clinical Research Facility
Mail Stop: 4253
Office Phone: (979) 220-2910
E-mail:
Other Title: Ponder Endowed Chair
Directory Title: Director Center for Translational Research Aging
Primary Emphasis Area: Kinesiology
Vita: View Document
Google Scholar: Google Scholar Profile
Short Bio
Experience : Dr. Nicolaas Deutz, MD, PhD currently serves as Director for the Center for Translational Research in Aging and Longevity (CTRAL). For more than 30 years, his research background and expertise focus on nutrition, metabolism, and physiology studies involving the use of stable isotope methodologies, both in humans and animals. Dr. Deutz has extensive experience with isotopic calculations, validation and data interpretation. The stable isotope approaches are used in several studies to unravel the metabolic changes in patients with chronic diseases (i.e., chronic obstructive pulmonary disease, cancer, cystic fibrosis, chronic heart failure, obstructive sleep apnea, mild cognitive impairment and dementia, autism spectrum disorder). This research leads to new insights in protein and amino acid kinetics in subjects with chronic disease and resulted in specific recommendations to nutritional supplements as method for reducing muscle wasting. Recently, he started studying the anabolic effects of specialized nutritional supplements in different chronic diseases and models of disease. Using translational approaches is a logical extension of the body of his research in the field of protein and amino acids metabolism. Education: Dr. Deutz obtained his MD and PhD at the University of Amsterdam, Netherlands. He is a medical physiologist and Nutrition Physician Specialist. Learn more about Dr. Deutz by visiting his page on CTRAL's website
Research Interests
amino acids
chroninc disease
clinical nutrition
older adults
proteins
Publications (journal articles, books, book chapters)*

1. Van der Meij B.S., *De Groot L.M., Deutz N.E.P., Engelen M.P.K.J. Effects of acute oral feeding on protein metabolism and muscle protein synthesis in people with cancer. Nutrition 2019: In press (In Press)

2. Luiking YC, Poeze M, Deutz NE. A randomized-controlled trial of arginine infusion in severe sepsis on microcirculation and metabolism. Clin Nutr. 2019. Epub 2019/09/17. doi: 10.1016/j.clnu.2019.08.013. PubMed PMID: 31522785.

3. Ilaiwy A, Ten Have GAM, Bain JR, Muehlbauer MJ, O'Neal SK, Berthiaume JM, Parry TL, Deutz NE, Willis MS. Identification of Metabolic Changes in Ileum, Jejunum, Skeletal Muscle, Liver, and Lung in a Continuous I.V. Pseudomonas aeruginosa Model of Sepsis Using Nontargeted Metabolomics Analysis. Am J Pathol. 2019;189(9):1797-813. Epub 2019/08/24. doi: 10.1016/j.ajpath.2019.05.021. PubMed PMID: 31439155; PMCID: PMC6723233.

4. van der Meij BS, De Groot LM, Deutz NEP, Engelen M. Effects of acute oral feeding on protein metabolism and muscle protein synthesis in individuals with cancer. Nutrition. 2019;67-68:110531. Epub 2019/08/16. doi: 10.1016/j.nut.2019.06.012. PubMed PMID: 31415909.

5. van der Meij BS, Deutz NEP, Rodriguez RER, Engelen M. Increased amino acid turnover and myofibrillar protein breakdown in advanced cancer are associated with muscle weakness and impaired physical function. Clin Nutr. 2019;38(5):2399-407. Epub 2018/11/28. doi: 10.1016/j.clnu.2018.10.022. PubMed PMID: 30477932.

6. Ten Have GAM, Engelen M, Wolfe RR, Deutz NEP. Inhibition of jejunal protein synthesis and breakdown in Pseudomonas aeruginosa-induced sepsis pig model. American journal of physiology. 2019;316(6):G755-G62. Epub 2019/04/13. doi:

7. van der Meij BS, Teleni L, Engelen M, Deutz NEP. Amino acid kinetics and the response to nutrition in patients with cancer. International journal of radiation biology. 2019;95(4):480-92. Epub 2018/04/19. doi: 10.1080/09553002.2018.1466209. PubMed PMID: 29667485.

8. Engelen M, Ten Have GAM, Thaden JJ, Deutz NEP. New advances in stable tracer methods to assess whole-body protein and amino acid metabolism. Curr Opin Clin Nutr Metab Care. 2019;22(5):337-46. Epub 2019/06/14. doi: 10.1097/MCO.0000000000000583. PubMed PMID: 31192825.

9. Heyland DK, Day A, Clarke GJ, Hough CT, Files DC, Mourtzakis M, Deutz N, Needham DM, Stapleton R. Nutrition and Exercise in Critical Illness Trial (NEXIS Trial): a protocol of a multicentred, randomised controlled trial of combined cycle ergometry and amino acid supplementation commenced early during critical illness. BMJ open. 2019;9(7):e027893. Epub 2019/08/03. doi: 10.1136/bmjopen-2018-027893. PubMed PMID: 31371287; PMCID: PMC6678006.

10. Jonker R, Deutz NEP, Ligthart-Melis GC, Zachria AJ, Veley EA, Harrykissoon R, Engelen M. Preserved anabolic threshold and capacity as estimated by a novel stable tracer approach suggests no anabolic resistance or increased requirements in weight stable COPD patients. Clin Nutr. 2019;38(4):1833-43. Epub 2018/08/14. doi: 10.1016/j.clnu.2018.07.018. PubMed PMID: 30100106; PMCID: PMC6355392.

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* Publication was joint-authored with students
Diss Publication was from a dissertation
ROS Publication was from a record of study

College of Education and Human Development Grants and Contracts (Current)

Engineering Research Center for Precise Advanced Technologies andHealth Systems for Underserved Populations (PATHS-UP). (Co-PI)
National Science Foundation (Federal)
2017/08/01 - 2022/07/31
Total Funding: 28,545.

Nutrition and Exercise in Critical Illness (The NEXIS Trial): A Randomized Trail of Combined Cycle Ergometry and Amino Acids in the ICU. (PI)
University of Vermont - NIH (Federal)
2017/04/01 - 2022/03/31
Total Funding: 112,697.
Courses Taught
2019 - 2020
KINE 690
2018 - 2019
KINE 690
2012 - 2013
KINE 685
Editorial Positions

Associate Editor (2014 - ). Clinical Nutrition Experimental

Editorial Board Member (2008 - ). American Journal of Physiology: Endocrinology and Metabolism

Editor (2005 - ). Clinical Nutrition

Editor (2005 - ). e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism;

Awards

(2013-2013). ESPEN Followship.  Effect of enteral nutritional intervention on glutathione metabolism during Pseudomonas aeruginosa induced sepsis in the pig

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