Directory » NICOLAAS DEUTZ
125
220-2910
Experience : Dr. Nicolaas Deutz, MD, PhD currently serves as Director for the Center for Translational Research in Aging and Longevity (CTRAL). For more than 30 years, his research background and expertise focus on nutrition, metabolism, and physiology studies involving the use of stable isotope methodologies, both in humans and animals. Dr. Deutz has extensive experience with isotopic calculations, validation and data interpretation. The stable isotope approaches are used in several studies to unravel the metabolic changes in patients with chronic diseases (i.e., chronic obstructive pulmonary disease, cancer, cystic fibrosis, chronic heart failure, obstructive sleep apnea, mild cognitive impairment and dementia, autism spectrum disorder). This research leads to new insights in protein and amino acid kinetics in subjects with chronic disease and resulted in specific recommendations to nutritional supplements as method for reducing muscle wasting. Recently, he started studying the anabolic effects of specialized nutritional supplements in different chronic diseases and models of disease. Using translational approaches is a logical extension of the body of his research in the field of protein and amino acids metabolism.
Education: Dr. Deutz obtained his MD and PhD at the University of Amsterdam, Netherlands.
He is a medical physiologist and Nutrition Physician Specialist. Learn more about Dr. Deutz by visiting CTRAL's website
Education: Dr. Deutz obtained his MD and PhD at the University of Amsterdam, Netherlands.
He is a medical physiologist and Nutrition Physician Specialist. Learn more about Dr. Deutz by visiting CTRAL's website
COURSES TAUGHT
KINE685. DIRECTED STUDIES
2013B
KINE690. THEORY OF KINE RSCH
2019B
KINE690. THEORY OF RES IN DISCI
2020C,2020A,2019C
FORMER DOCTORAL STUDENTS
Sarah Kirschner, Ph.D. (Summer 2023)
Taylor Paige Graves Boswell, Ph.D. (Spring 2022)
SELECTED PUBLICATIONS
Journal Articles
Engelen M, Ten Have GAM, Thaden JJ, Deutz NEP. New advances in stable tracer methods to assess whole-body protein and amino acid metabolism. Curr Opin Clin Nutr Metab Care. 2019;22(5):337-46. Epub 2019/06/14. doi: 10.1097/MCO.0000000000000583. PubMed PMID: 31192825.
Heyland DK, Day A, Clarke GJ, Hough CT, Files DC, Mourtzakis M, Deutz N, Needham DM, Stapleton R. Nutrition and Exercise in Critical Illness Trial (NEXIS Trial): a protocol of a multicentred, randomised controlled trial of combined cycle ergometry and amino acid supplementation commenced early during critical illness. BMJ open. 2019;9(7):e027893. Epub 2019/08/03. doi: 10.1136/bmjopen-2018-027893. PubMed PMID: 31371287; PMCID: PMC6678006.
Ilaiwy A, Ten Have GAM, Bain JR, Muehlbauer MJ, O'Neal SK, Berthiaume JM, Parry TL, Deutz NE, Willis MS. Identification of Metabolic Changes in Ileum, Jejunum, Skeletal Muscle, Liver, and Lung in a Continuous I.V. Pseudomonas aeruginosa Model of Sepsis Using Nontargeted Metabolomics Analysis. Am J Pathol. 2019;189(9):1797-813. Epub 2019/08/24. doi: 10.1016/j.ajpath.2019.05.021. PubMed PMID: 31439155; PMCID: PMC6723233.
Jonker R, Deutz NEP, Ligthart-Melis GC, Zachria AJ, Veley EA, Harrykissoon R, Engelen M. Preserved anabolic threshold and capacity as estimated by a novel stable tracer approach suggests no anabolic resistance or increased requirements in weight stable COPD patients. Clin Nutr. 2019;38(4):1833-43. Epub 2018/08/14. doi: 10.1016/j.clnu.2018.07.018. PubMed PMID: 30100106; PMCID: PMC6355392.
Jonker R, Deutz NEP, Schols A, Veley EA, Harrykissoon R, Zachria AJ, Engelen M. Whole body protein anabolism in COPD patients and healthy older adults is not enhanced by adding either carbohydrates or leucine to a serving of protein. Clin Nutr. 2019;38(4):1684-91. Epub 2018/08/29. doi: 10.1016/j.clnu.2018.08.006. PubMed PMID: 30150004; PMCID: PMC6377853.
Lobo DN, Deutz NEP. Publication governance in Clinical Nutrition. Clin Nutr. 2019. Epub 2019/11/26. doi: 10.1016/j.clnu.2019.11.010. PubMed PMID: 31761391.
Loman BR, Luo M, Baggs GE, Mitchell DC, Nelson JL, Ziegler TR, Deutz NE, Matarese LE, Group NS. Specialized High-Protein Oral Nutrition Supplement Improves Home Nutrient Intake of Malnourished Older Adults Without Decreasing Usual Food Intake. JPEN J Parenter Enteral Nutr. 2019;43(6):794-802. Epub 2018/12/20. doi: 10.1002/jpen.1467. PubMed PMID: 30565718.
Luiking YC, Poeze M, Deutz NE. A randomized-controlled trial of arginine infusion in severe sepsis on microcirculation and metabolism. Clin Nutr. 2019. Epub 2019/09/17. doi: 10.1016/j.clnu.2019.08.013. PubMed PMID: 31522785.
Ten Have GAM, Engelen M, Wolfe RR, Deutz NEP. Inhibition of jejunal protein synthesis and breakdown in Pseudomonas aeruginosa-induced sepsis pig model. American journal of physiology. 2019;316(6):G755-G62. Epub 2019/04/13. doi:
van der Meij BS, De Groot LM, Deutz NEP, Engelen M. Effects of acute oral feeding on protein metabolism and muscle protein synthesis in individuals with cancer. Nutrition. 2019;67-68:110531. Epub 2019/08/16. doi: 10.1016/j.nut.2019.06.012. PubMed PMID: 31415909.
Van der Meij B.S., *De Groot L.M., Deutz N.E.P., Engelen M.P.K.J. Effects of acute oral feeding on protein metabolism and muscle protein synthesis in people with cancer. Nutrition 2019: In press
van der Meij BS, Deutz NEP, Rodriguez RER, Engelen M. Increased amino acid turnover and myofibrillar protein breakdown in advanced cancer are associated with muscle weakness and impaired physical function. Clin Nutr. 2019;38(5):2399-407. Epub 2018/11/28. doi: 10.1016/j.clnu.2018.10.022. PubMed PMID: 30477932.
van der Meij BS, Teleni L, Engelen M, Deutz NEP. Amino acid kinetics and the response to nutrition in patients with cancer. International journal of radiation biology. 2019;95(4):480-92. Epub 2018/04/19. doi: 10.1080/09553002.2018.1466209. PubMed PMID: 29667485.
Adolph M, Calder PC, Deutz NE, Carmona TG, Klek S, Lev S, Mayer K, Michael-Titus AT, Pradelli L, Puder M, Singer P, Vlaardingerbroek H. Commentary on "Fish Oil-Containing Lipid Emulsions in Adult Parenteral Nutrition: A Review of the Evidence" (https://doi.org/10.1177/0148607117721907). JPEN J Parenter Enteral Nutr. 2018. Epub 2018/04/01. doi: 10.1002/jpen.1047. PubMed PMID: 29603280.
Barnes RC, Kim H, Fang C, Bennett W, Nemec M, Sirven MA, Suchodolski JS, Deutz N, Britton RA, Mertens-Talcott SU, Talcott ST. Body Mass Index as a Determinant of Systemic Exposure to Gallotannin Metabolites during 6-Week Consumption of Mango (Mangifera indica L.) and Modulation of Intestinal Microbiota in Lean and Obese Individuals. Molecular nutrition & food research. 2018;0(ja):e1800512. Epub 2018/11/15. doi: 10.1002/mnfr.201800512. PubMed PMID: 30427574.
Calder PC, Adolph M, Deutz NE, Grau T, Innes JK, Klek S, Lev S, Mayer K, Michael-Titus AT, Pradelli L, Puder M, Vlaardingerbroek H, Singer P. Lipids in the intensive care unit: Recommendations from the ESPEN Expert Group. Clin Nutr. 2018;37(1):1-18. Epub 2017/09/25. doi: 10.1016/j.clnu.2017.08.032. PubMed PMID: 28935438.
Deutz NEP, Thaden JJ, Ten Have GAM, Walker DK, Engelen M. Metabolic phenotyping using kinetic measurements in young and older healthy adults. Metabolism: clinical and experimental. 2018;78:167-78. Epub 2017/10/08. doi: 10.1016/j.metabol.2017.09.015. PubMed PMID: 28986165; PMCID: PMC5732887.
Deutz N.E.P., Thaden J.J., *Ten Have G.A.M., Walker D.K., Engelen M.P.K.J. Metabolic phenotyping using kinetic measurements in young and older healthy adults. Metabolism 2018: 78:167-178
Eggink HM, van Nierop FS, Schooneman MG, Boelen A, Kalsbeek A, Koehorst M, Ten Have GAM, de Brauw LM, Groen AK, Romijn JA, Deutz NEP, Soeters MR. Transhepatic bile acid kinetics in pigs and humans. Clin Nutr. 2018;37(4):1406-14. Epub 2017/07/04. doi: 10.1016/j.clnu.2017.06.015. PubMed PMID: 28669667.
Engelen M, Deutz NEP. Is beta-hydroxy beta-methylbutyrate an effective anabolic agent to improve outcome in older diseased populations? Curr Opin Clin Nutr Metab Care. 2018;21(3):207-13. Epub 2018/02/07. doi: 10.1097/MCO.0000000000000459. PubMed PMID: 29406417; PMCID: PMC5882564.
Engelen M, Klimberg VS, Allasia A, Deutz NEP. Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer. Clin Nutr. 2018;37(5):1645-53. Epub 2017/08/23. doi: 10.1016/j.clnu.2017.07.019. PubMed PMID: 28826699; PMCID: PMC5799041.
Engelen M.P.K.J., Deutz N.E.P. Is HMB an effective anabolic agent to improve outcome in diseased populations? Current Opinion in Clinical Nutrition & Metabolic Care. 2018: 21:207-213
Engelen M.P.K.J., Klimberg V.S., *Allasia A, Deutz N.E.P. Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer. Clinical Nutrition 2018: 37: 1645-53
Fan YY, Fuentes NR, Hou TY, Barhoumi R, Li XC, Deutz NEP, Engelen M, McMurray DN, Chapkin RS. Remodelling of primary human CD4 T cell plasma membrane order by n-3 PUFA. Br J Nutr. 2018;119(2):163-75. Epub 2017/12/19. doi: 10.1017/S0007114517003385. PubMed PMID: 29249211; PMCID: PMC5927572.
Fan Y.Y., Fuentes N.R., Hou T.Y., Barhoumi R., Li X.C., Deutz N.E.P., Engelen M.P.K.J., McMurray D.N. and Chapkin R.S. Remodelling of primary human CD4 T cell plasma membrane 2 order by n-3 PUFA, Br J Nutr 2018: 119:163-175
Jonker R, Deutz NEP, Harrykissoon R, Zachria AJ, Veley EA, Engelen M. A critical evaluation of the anabolic response after bolus or continuous feeding in COPD and healthy older adults. Clin Sci (Lond). 2018;132(1):17-31. Epub 2017/12/01. doi: 10.1042/CS20171068. PubMed PMID: 29187513.
Jonker R., Deutz N.E.P., Harrykissoon R., Zachria A.J., Veley E.A., Engelen M.P.K.J. A critical evaluation of the anabolic response after bolus or continuous feeding in COPD and healthy older adults. Clinical Science. 2018: 132:17-31
Kim IY, Deutz NEP, Wolfe RR. Update on maximal anabolic response to dietary protein. Clin Nutr. 2018;37(2):411-8. Epub 2017/08/16. doi: 10.1016/j.clnu.2017.05.029. PubMed PMID: 28807333.
Lieben CK, Blokland A, Deutz NE, Jansen W, Han G, Hupperts RM. Intake of tryptophan-enriched whey protein acutely enhances recall of positive loaded words in patients with multiple sclerosis. Clin Nutr. 2018;37(1):321-8. Epub 2017/02/06. doi: 10.1016/j.clnu.2016.12.029. PubMed PMID: 28153503.
Prado CM, Purcell SA, Alish C, Pereira SL, Deutz NE, Heyland DK, Goodpaster BH, Tappenden KA, Heymsfield SB. Implications of low muscle mass across the continuum of care: a narrative review. Annals of medicine. 2018:1-19. Epub 2018/09/01. doi: 10.1080/07853890.2018.1511918. PubMed PMID: 30169116.
Ten Have GAM, Deutz RCI, Engelen M, Wolfe RR, Deutz NEP. Characteristics of a Pseudomonas aeruginosa induced porcine sepsis model for multi-organ metabolic flux measurements. Lab Anim. 2018;52(2):163-75. Epub 2017/07/07. doi: 10.1177/0023677217718003. PubMed PMID: 28679339.
van der Meij BS, Teleni L, Engelen M, Deutz NEP. Amino acid kinetics and the response to nutrition in patients with cancer. International journal of radiation biology. 2018:1-13. Epub 2018/04/19. doi: 10.1080/09553002.2018.1466209. PubMed PMID: 29667485.
Van der Meij B.S., Teleni L, Engelen M.P.K.J., Deutz N.E.P. Amino Acid Kinetics and the Response to Nutrition in Patients with Cancer. International Journal of Radiation Biology 2018: 3:1-13
van Zwol A, Oosterloo NBC, de Betue CT, Bogers A, de L, II, Deutz NEP, Joosten KFM. Effects of glucocorticoids on serum amino acid levels during cardiac surgery in children. Clin Nutr ESPEN. 2018;23:212-6. Epub 2018/02/21. doi: 10.1016/j.clnesp.2017.09.012. PubMed PMID: 29460801
Arends J, Baracos V, Bertz H, Bozzetti F, Calder PC, Deutz NEP, Erickson N, Laviano A, Lisanti MP, Lobo DN, McMillan DC, Muscaritoli M, Ockenga J, Pirlich M, Strasser F, de van der Schueren M, Van Gossum A, Vaupel P, Weimann A. ESPEN expert group recommendations for action against cancer-related malnutrition. Clin Nutr. 2017;36(5):1187-96. Epub 2017/07/12. doi: 10.1016/j.clnu.2017.06.017. PubMed PMID: 28689670.
Barazzoni R, Deutz NEP, Biolo G, Bischoff S, Boirie Y, Cederholm T, Cuerda C, Delzenne N, Leon Sanz M, Ljungqvist O, Muscaritoli M, Pichard C, Preiser JC, Sbraccia P, Singer P, Tappy L, Thorens B, Van Gossum A, Vettor R, Calder PC. Carbohydrates and insulin resistance in clinical nutrition: Recommendations from the ESPEN expert group. Clin Nutr. 2017;36(2):355-63. Epub 2016/10/01. doi: 10.1016/j.clnu.2016.09.010. PubMed PMID: 27686693.
Bosoi CR, Oliveira MM, Ochoa-Sanchez R, Tremblay M, Ten Have GA, Deutz NE, Rose CF, Bemeur C. The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis. Metabolic brain disease. 2017;32(2):513-8. Epub 2016/12/17. doi: 10.1007/s11011-016-9937-4. PubMed PMID: 27981407.
de Betue CTI, Garcia Casal XC, van Waardenburg DA, Schexnayder SM, Joosten KFM, Deutz NEP, Engelen M. 24-Hour protein, arginine and citrulline metabolism in fed critically ill children - A stable isotope tracer study. Clin Nutr. 2017;36(3):876-87. Epub 2017/01/17. doi: 10.1016/j.clnu.2016.12.023. PubMed PMID: 28089618; PMCID: PMC5404980.
Deutz NE, Simbo SY, Ligthart-Melis GC, Cynober L, Smriga M, Engelen MP. Tolerance to increased supplemented dietary intakes of methionine in healthy older adults. Am J Clin Nutr. 2017;106(2):675-83. Epub 2017/06/24. doi: 10.3945/ajcn.117.152520. PubMed PMID: 28637772.
Engelen M, Klimberg VS, Allasia A, Deutz NE. Presence of early stage cancer does not impair the early protein metabolic response to major surgery. Journal of cachexia, sarcopenia and muscle. 2017;8(3):447-56. Epub 2017/01/18. doi: 10.1002/jcsm.12173. PubMed PMID: 28093897; PMCID: PMC5476851
Hakvoort, T., He, Y., Kulik, W., Vermeulen, J. L., Duijst, S., Ruijter, J. M., Runge, JH, Deutz, N.E.P., Koehler, S.E., Lamers, W. H. (2017). Pivotal role of glutamine synthetase in ammonia detoxification. Hepatology, 65(1), 281-293
Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults. Metabolism: clinical and experimental. 2017;69:120-9. Epub 2017/03/14. doi: 10.1016/j.metabol.2016.12.010. PubMed PMID: 28285641; PMCID: PMC5351771.
Kumar A, Davuluri G, Silva RNE, Engelen M, Ten Have GAM, Prayson R, Deutz NEP, Dasarathy S. Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis. Hepatology. 2017;65(6):2045-58. Epub 2017/02/15. doi: 10.1002/hep.29107. PubMed PMID: 28195332; PMCID: PMC5444955.
Mason A, Engelen M, Ivanov I, Toffolo GM, Deutz NEP. A four-compartment compartmental model to assess net whole body protein breakdown using a pulse of phenylalanine and tyrosine stable isotopes in humans. American journal of physiology Endocrinology and metabolism. 2017;313(1):E63-E74. Epub 2017/03/09. doi: 10.1152/ajpendo.00362.2016. PubMed PMID: 28270442.
Miousse IR, Pathak R, Garg S, Skinner CM, Melnyk S, Pavliv O, Hendrickson H, Landes RD, Lumen A, Tackett AJ, Deutz NEP, Hauer-Jensen M, Koturbash I. Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology. Genes Nutr. 2017;12(1):22. Epub 2017/09/15. doi: 10.1186/s12263-017-0576-0. PubMed PMID: 28904640; PMCID: PMC5588631.
Standley RA, Distefano G, Pereira SL, Tian M, Kelly OJ, Coen PM, Deutz NEP, Wolfe RR, Goodpaster BH. Effects of beta-hydroxy-beta-methylbutyrate on skeletal muscle mitochondrial content and dynamics, and lipids after 10 days of bed rest in older adults. J Appl Physiol (1985). 2017;123(5):1092-100. Epub 2017/07/15. doi: 10.1152/japplphysiol.00192.2017. PubMed PMID: 28705993.
Ten Have GAM, Engelen M, Wolfe RR, Deutz NEP. Phenylalanine isotope pulse method to measure effect of sepsis on protein breakdown and membrane transport in the pig. American journal of physiology Endocrinology and metabolism. 2017;312(6):E519-E29. Epub 2017/03/16. doi: 10.1152/ajpendo.00351.2016. PubMed PMID: 28292760; PMCID: PMC5494580.
Walker DK, Thaden JJ, Wierzchowska-McNew A, Engelen M, Deutz NEP. Determination of beta-hydroxy-beta-methylbutyrate concentration and enrichment in human plasma using chemical ionization gas chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1040:233-8. Epub 2016/11/20. doi: 10.1016/j.jchromb.2016.11.010. PubMed PMID: 27856194; PMCID: PMC5191936.
Walton BM, Jackson GW, Deutz N, Cote G. Surface-enhanced Raman spectroscopy competitive binding biosensor development utilizing surface modification of silver nanocubes and a citrulline aptamer. J Biomed Opt. 2017;22(7):75002. Epub 2017/07/22. doi: 10.1117/1.JBO.22.7.075002. PubMed PMID: 28732094; PMCID: PMC5521305.
Deutz NE, Matheson EM, Matarese LE, Baggs GE, Nelson JL, Hegazi RA, Luo M, Tappenden KA, Ziegler TR, Group NS. Reply, Letter to the Editor - Supplemental and energy likely account for multi-ingredient supplementation in mitigating morbidity and mortality in compromised elderly malnourished patients. Clin Nutr. 2016. doi: 10.1016/j.clnu.2016.03.027. PubMed PMID: 27091771
Engelen MP, Safar AM, Bartter T, Koeman F, Deutz NE. Reduced arginine availability and nitric oxide synthesis in cancer is related to impaired endogenous arginine synthesis. Clinical Science. 2016. Doi: 10.1042/cs20160233
Engelen MP, van der Meij BS, Deutz NE. Protein anabolic resistance in cancer: does it really exist? Curr Opin Clin Nutr Metab Care. 2016;19(1):39-47. doi: 10.1097/MCO.0000000000000236. PubMed PMID: 26560520
Engelen MP, van der Meij BS, Deutz NE. Protein anabolic resistance in cancer: does it really exist? Curr Opin Clin Nutr Metab Care. 2016;19(1):39-47. doi: 10.1097/MCO.0000000000000236. PubMed PMID: 26560520; PMCID: PMC4731087.
Heyland DK, Stapleton RD, Mourtzakis M, Hough CL, Morris P, Deutz NE, Colantuoni E, Day A, Prado CM, Needham DM. Combining nutrition and exercise to optimize survival and recovery from critical illness: Conceptual and methodological issues. Clin Nutr. 2016;35(5):1196-206. doi: 10.1016/j.clnu.2015.07.003. PubMed PMID: 26212171
Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease. Am J Clin Nutr. 2016. doi: 10.3945/ajcn.115.125187. PubMed PMID: 27146652
Oshima T, Deutz NE, Doig G, Wischmeyer PE, Pichard C. Protein-energy nutrition in the ICU is the power couple: A hypothesis forming analysis. Clin Nutr. 2016;35(4):968-74. doi: 10.1016/j.clnu.2015.10.016. PubMed PMID: 26608526
Coker RH, Deutz NE, Schutzler S, Beggs M, Miller S, Wolfe RR, Wei J. Nutritional Supplementation with Essential Amino Acids and Phytosterols May Reduce Risk for Metabolic Syndrome and Cardiovascular Disease in Overweight Individuals with Mild Hyperlipidemia. Journal of Endocrinology, Diabetes & Obesity. 2015;3(2):1069
Deutz NE, Matheson EM, Matarese LE, Luo M, Baggs GE, Nelson JL, Hegazi RA, Tappenden KA, Ziegler TR, Group NS. Readmission and mortality in malnourished, older, hospitalized adults treated with a specialized oral nutritional supplement: A randomized clinical trial. Clin Nutr. 2016. doi: 10.1016/j.clnu.2015.12.010. PubMed PMID: 26797412
Engelen MP, Safar AM, Bartter T, Koeman F, Deutz NE. High anabolic potential of essential amino acid mixtures in advanced nonsmall cell lung cancer. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 2015;26(9):1960-6. doi: 10.1093/annonc/mdv271. PubMed PMID: 26113648; PMCID: PMC4551158
Kim IY, Schutzler SE, Schrader A, Spencer HJ, Azhar G, Deutz NE, Wolfe RR. Acute ingestion of citrulline stimulates nitric oxide synthesis but does not increase blood flow in healthy young and older adults with heart failure. American journal of physiology. 2015;309(11):E915-24. doi: 10.1152/ajpendo.00339.2015
Kim IY, Schutzler S, Schrader A, Spencer H, Kortebein P, Deutz NE, Wolfe RR, Ferrando AA. Quantity of dietary protein intake, but not pattern of intake, affects net protein balance primarily through differences in protein synthesis in older adults. American journal of physiology. 2015;308(1):E21-8. doi: 10.1152/ajpendo.00382.2014. PubMed PMID: 25352437
Ligthart-Melis GC, Marini JC, Engelen MP, Deutz NE. Glutamine supplementation, citrulline production, and de novo arginine synthesis: is there a relation? The American Journal of Clinical Nutrition. 2015;101(4):890-2. doi: 10.3945/ajcn.114.104679.
Luiking YC, Poeze M, Deutz NE. Arginine infusion in patients with septic shock increases nitric oxide production without haemodynamic instability. Clin Sci (Lond). 2015;128(1):57-67. doi: 10.1042/CS20140343. PubMed PMID: 25036556.
Schooneman MG, Ten Have GA, van Vlies N, Houten SM, Deutz NE, Soeters MR. Transorgan fluxes in a porcine model reveal a central role for liver in acylcarnitine metabolism. American journal of physiology. 2015;309(3):E256-64. doi: 10.1152/ajpendo.00503.2014. PubMed PMID: 26037250
Ten Have GA, van der Pijl PC, Kies AK, Deutz NE. Enhanced Lacto-Tri-Peptide Bio-Availability by Co-Ingestion of Macronutrients. PLoS One. 2015;10(6):e0130638. doi: 10.1371/journal.pone.0130638. PubMed PMID: 26098114; PMCID: PMC4476664.
Tsien C, Davuluri G, Singh D, Allawy A, Ten Have GA, Thapaliya S, Schulze JM, Barnes D, McCullough AJ, Engelen MP, Deutz NE, Dasarathy S. Metabolic and molecular responses to leucine enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis. Hepatology (Baltimore, Md. 2015. doi: 10.1002/hep.27717. PubMed PMID: 25613922.
van Dijk DP, van de Poll MC, Moses AG, Preston T, Olde Damink SW, Rensen SS, Deutz NE, Soeters PB, Ross JA, Fearon K, Dejong CH. Effects of oral meal feeding on whole body protein breakdown and protein synthesis in cachectic pancreatic cancer patients. Journal of cachexia, sarcopenia and muscle. 2015;6(3):212-21. doi: 10.1002/jcsm.12029. PubMed PMID: 26401467; PMCID: PMC4575552
Walker DK, Thaden JJ, Deutz NEP. Application of gas chromatography[48]13tandem mass spectrometry (GC/MS/MS) for the analysis of deuterium enrichment of water. Journal of Mass Spectrometry. 2015;50(6):838-43. doi: 10.1002/jms.3593.
Deutz NE, Bauer JM, Barazzoni R, Biolo G, Boirie Y, BosyWestphal A, Cederholm T, CruzJentoft A, Krznaric Z, Nair KS, Singer P, Teta D, Tipton K, Calder PC. Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group. Clin Nutr. 2014[894]33(6):92936. doi: 10.1016/j.clnu.2014.04.007. PubMed PMID: 24814383[894] PMCID: 4208946.
Elliott TB, Deutz NE, Gulani J, Koch A, Olsen CH, Christensen C, Chappell M, Whitnall MH, Moroni M. Gastrointestinal acute radiation syndrome in gottingen minipigs (sus scrofa domestica). Comparative medicine. 2014;64(6):456-63. PubMed PMID: 25527026.
Engelen MP, Com G, Deutz NE. Increased whole body hydroxyproline production as assessed by a new stable isotope technique is associated with hip and spine bone mineral loss in cystic fibrosis. Clin Nutr. 2014;33(6):1117-21. doi: 10.1016/j.clnu.2013.12.008. PubMed PMID: 24423745.
Engelen M.P.K.J. Com G., Anderson P.J., Deutz N.E.P. New Stable Isotope Method to Measure Protein Digestibility and Response to Pancreatic Enzyme Intake in Cystic Fibrosis, Clin. Nutr. 2014, 33: 1024-32
Engelen MPKJ, Com G, Deutz NEP. Protein is an important but undervalued macronutrient in the nutritional care of patients with cystic fibrosis. Current Opinion in Clinical Nutrition & Metabolic Care. 2014;17 (6), 515-520. Publish Ahead of Print:10.1097/MCO.0000000000000100.
Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Hydrolyzed casein and whey protein meals comparably stimulate net whole-body protein synthesis in COPD patients with nutritional depletion without an additional effect of leucine co-ingestion. Clin Nutr. 2014;33(2):211-20. doi: 10.1016/j.clnu.2013.06.014. PubMed PMID: 23886411; PubMed Central PMCID: PMC3883994.
Luiking YC, Deutz NE, Memelink RG, Verlaan S, Wolfe RR. Postprandial muscle protein synthesis is higher after a high whey protein, leucine-enriched supplement than after a dairy-like product in healthy older people: a randomized controlled trial. Nutrition journal. 2014;13(1):9. doi: 10.1186/1475-2891-13-9. PubMed PMID: 24450500; PubMed Central PMCID: PMC3909458.
Moroni M, Elliott TB, Deutz NE, Olsen CH, Owens R, Christensen C, Lombardini ED, Whitnall MH. Accelerated hematopoietic syndrome after radiation doses bridging hematopoietic (H-ARS) and gastrointestinal (GI-ARS) acute radiation syndrome: early hematological changes and systemic inflammatory response syndrome in minipig. International journal of radiation biology. 2014;90(5):363-72. doi: 10.3109/09553002.2014.892226. PubMed PMID: 24524283
de Betue CT, Joosten KF, Deutz NE, Vreugdenhil AC, van Waardenburg DA. Arginine appearance and nitric oxide synthesis in critically ill infants can be increased with a protein-energy-enriched enteral formula. Am J Clin Nutr. 2013;98(4):907-16
Deutz NE, Pereira SL, Hays NP, Oliver JS, Edens NK, Evans CM, Wolfe RR. Effect of beta-hydroxy-beta-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults. Clin Nutr. 2013;32(5):704-12
Deutz NE, Pereira SL, Hays NP, Oliver JS, Edens NK, Evans CM, Wolfe RR. Effect of betahydroxybetamethylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults. Clin Nutr. 2013[894]32(5):70412. doi: 10.1016/j.clnu.2013.02.011. PubMed PMID: 23514626.
Engelen MP, Com G, Luiking YC, Deutz NE. Stimulated nitric oxide production and arginine deficiency in children with cystic fibrosis with nutritional failure. The Journal of pediatrics. 2013;163(2):369-75
Engelen M.P.K.J., Com G., Wolfe R.R., Deutz N.E.P. Dietary essential amino acids are highly anabolic in pediatric patients with Cystic Fibrosis. J. Cystic Fibrosis. 2013:12: 45[8211]453
Jourdan M, Deutz NE, Cynober L, Aussel C. Consequences of age-related splanchnic sequestration of leucine on interorgan glutamine metabolism in old rats. J Appl Physiol (1985). 2013;115(2):229-34
Deutz NE, Wolfe RR. Is there a maximal anabolic response to protein intake with a meal? Clin Nutr. 2013[894]32(2):30913. doi: 10.1016/j.clnu.2012.11.018. PubMed PMID: 23260197[894] PMCID: 3595342.
Engelen, M. P., De Castro, C. L., Rutten, E. P., Wouters, E. F., Schols, A. M., & Deutz, N. E. (2012). Enhanced anabolic response to milk protein sip feeding in elderly subjects with COPD is associated with a reduced splanchnic extraction of multiple amino acids. Clin Nutr, 31(5), 616-624
Engelen, M. P., Rutten, E. P., De Castro, C. L., Wouters, E. F., Schols, A. M., & Deutz, N. E. (2012). Casein protein results in higher prandial and exercise induced whole body protein anabolism than whey protein in chronic obstructive pulmonary disease. Metabolism, 61(9), 1289-1300
Engelen, M. P., Schroder, R., Van der Hoorn, K., Deutz, N. E., & Com, G. (2012). Use of body mass index percentile to identify fat-free mass depletion in children with cystic fibrosis. Clin Nutr
Jonker, R., Engelen, M. P., & Deutz, N. E. (2012). Role of specific dietary amino acids in clinical conditions. Br J Nutr, 108 Suppl 2(S2), S139-148
Luiking, Y. C., Ten Have, G. A., Wolfe, R. R., & Deutz, N. E. (2012). Arginine de novo and nitric oxide production in disease states. Am J Physiol Endocrinol Metab, 303(10), E1177-1189
Mpabanzi, L., Deutz, N., Hayes, P. C., Dejong, C. H., Olde Damink, S. W., & Jalan, R. (2012). Overnight glucose infusion suppresses renal ammoniagenesis and reduces hyperammonaemia induced by a simulated bleed in cirrhotic patients. Aliment Pharmacol Ther, 35(8), 921-928
Sharma, V., Ten Have, G. A., Ytrebo, L., Sen, S., Rose, C. F., Dalton, R. N., Turner, C., Revhaug, A., van-Eijk, H. M., Deutz, N. E., Jalan, R., Mookerjee, R. P., Davies, N. A.. (2012). Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure. Am J Physiol Gastrointest Liver Physiol, 303(3), G435-441
Ten Have, G. A., Engelen, M. P., Soeters, P. B., & Deutz, N. E. (2012). Absence of post-prandial gut anabolism after intake of a low quality protein meal. Clin Nutr, 31(2), 273-282
Book Chapters
de Betue CT, Deutz NE. Changes in Arginine Metabolism during Sepsis and Critical Illness in Children. Nestle Nutrition Institute workshop series. 2013;77:17-28
Luiking, Y. C., Castillo, L., & Deutz, N. E. P. (2012). ARGININE, CITRULLINE AND NITRIC OXIDE. In A. C. Ross, B. Caballero, R. J. Cousins, K. L. Tucker & T. R. Ziegler (Eds.), The 11th edition of Modern Nutrition in Health and Disease: ; Lippincott Williams & Wilkins; Eleventh edition
Other Publications and Presentations
Gomes F, Baumgartner A, Bounoure L, Bally M, Deutz NE, Greenwald JL, Stanga Z, Mueller B, Schuetz P. Association of Nutritional Support With Clinical Outcomes Among Medical Inpatients Who Are Malnourished or at Nutritional Risk: An Updated Systematic Review and Meta-analysis. JAMA Netw Open. 2019;2(11):e1915138. Epub 2019/11/21. doi: 10.1001/jamanetworkopen.2019.15138. PubMed PMID: 31747030.
Ten Have GAM, Deutz RCI, Engelen M, Wolfe RR, Deutz NEP. Characteristics of a Pseudomonas aeruginosa induced porcine sepsis model for multi-organ metabolic flux measurements. Lab Anim. 2017:23677217718003. Epub 2017/07/07. doi: 10.1177/0023677217718003. PubMed PMID: 28679339.
RESEARCH PROJECTS
The role of adipose tissue estrogen receptor beta in obesity-induced insulin resistance
Mechanisms of motor impairments with obesity in males and females
The role of adipose tissue estrogen receptor beta in obesity-induced insulin resistance
Targeted nutritional approach to improve muscle function and physical activity by restoring metabolic deregulations during recovery from sepsis
APS Research Career Enhancement Award (RCEA)
Persistent Readiness through Early Prediction (PREP)
Targeted nutritional approach to improve muscle function and physical activity by restoring metabolic deregulations during recovery from sepsis
Targeted nutritional approach to improve muscle function and physical activity by restoring metabolic deregulations during recovery from sepsis
Targeted nutritional modulation to reduce intrinsic and exercise induced metabolic deregulations, and improve training responsiveness in Chronic Obstructive Pulmonary Disease with muscle dysfunction
Targeted nutritional modulation to reduce intrinsic and exercise induced metabolic deregulations, and improve training responsiveness in Chronic Obstructive Pulmonary Disease with muscle dysfunction
Improvement of Metabolism and Outcome by [223]-hydroxy [223]-methylbutyric (HMB) with Essential Amino Acid (EAA) Nutritional Supplementation in Sepsis
Targeted Nutritional Modulation to Reduce Intrinsic and Exercise Induced Metabolic Deregulations, and Improve Training Responsiveness in Chronic Obstructive Pulmonary Disease with Muscle Dysfunction
Mechanisms of Motor Function Impairments with Obesity and Advanced Age
Role of the Intestinal Microbiome in Uptake and Metabolism of Gallotannins and Inflammation in Obesity
PI. Texas A&M Agrilife Research - USDA National Institute of Food and Agriculture (Federal)
2019-03-01 — 2023-02-28
2019-03-01 — 2023-02-28
Nanoscale Deterministic Lateral Displacement Technology
SCH: INT: Personalized Models of Nutrition Intake from Continuous Glucose Monitors
Catapult #5
Identify the Metabolic Mechanisms and Systemic Factors Underlying Skeletal Muscle Dysfunction in COPD Patients with Abdominal Obesity and the Impact of Coexisting Sarcopenia
Nutritional modulation to minimize resistance exercise induced metabolic deregulations and improve training responsiveness in Chronic Obstructive Pulmonary Disease
Optimal Beta-Hydroxy-Beta-Methylbutyrate (HMB) with Essential Amino Acid (EAA) Nutritional Supplementation in Sepsis
IBM Sensor Testing
Nutritional modulation to minimize resistance exercise induced metabolic deregulations and improve training responsiveness in Chronic Obstructive Pulmonary Disease
Effects of Low Fose of Fish Oil (EPA+DHA) vs. combined EPA+DHA and HMB or Curcumin Supplementation on Protein Metabolism, Muscle Mass and Functional Capacity in Moderate to Severe COPD
HMB to reduce protein breakdown in sepsis
Preclinical Study in Pig Sepsis Model to Evaluate the Efficacy of HMB on Whole Body Protein Turnover using Pulse Labeling Methodology
Catapult Round 4 Center - CTRAL Clinical Research Symposium ($5,000)
Non-Invasive, Fully Integrated, Cybersecurity aware Closed-loop System for the Detection of Neurological Disorders?
Preserving Skeletal Muscle Morphology in Ground-based Microgravity with FDA Approved Interventions: Targeting OxidativeStress, Astronaut Age, and Synergism with Exercise
Role of Metabolic Phenotyping, Changes in Gut Function and the Response to a Meal to Explain the Variability in Weight Loss induced by Very Low Caloric Diet in (Morbidly) Obese Adults
Strategic Transformative Research Program: Assessment of Metabolism with Exhaled Breath Biomarkers
Engineering Research Center for Precise Advanced Technologies andHealth Systems for Underserved Populations (PATHS-UP)
BL 20 - Testing of blood samples for HMB and amino acids
A Randomized Double Blinded Controlled Trial of an Oral Nutritional Supplement Containing AN 777 in Older Hospitalized Patients
Nutrition and Exercise in Critical Illness (The NEXIS Trial): A Randomized Trail of Combined Cycle Ergometry and Amino Acids in the ICU
Catapult Round 3 - Linking Metabolic Phenotype to Mood and Neurocognitive Functions in Autism Spectrum Disorder (Funded amount $30,000)
Combined Amino Acid & Cycle Ergometry Exercise in Acute Respiratory Failure: RCT
ESPEN Research Fellowships
Pharmacokinetics of Bioactive Metabolites from Gallotannins
Development of Well-Characterized Mini-Pig Models of GI-ARS and H-ARS
PI. Henry M. Jackson Foundation - DOD-Uniformed Services University of the Health Sciences (Federal)
2016-06-01 — 2017-07-15
2016-06-01 — 2017-07-15
Human Metabolism of HMB
Feasibility of Novel Laboratory Methods for use in Nutrition Studies
Catapult Round 1 - Waking Up! Becoming Leaders in Sleep Research for Better Health and Learning (Funded amount $34,000)
Ellagi- and Gallotannins and Their Intestinal Microbial Metabolites in Preventing Gastro-Intestinal Inflammation: A Pharmacometric Approach
PI. Texas A&M Agrilife Research - USDA National Institute of Food and Agriculture (Federal)
2016-01-01 — 2018-12-31
2016-01-01 — 2018-12-31
Combined Amino Acid & Cycle Ergometry Exercise in Acute Respiratory Failure: RCT
Triheptanoin Treatment and Restoring Intermediary Metabolism in Type 2 Diabetes
Clinical Science and Translational Research (CSTR) Institute
Diet modulation of T cell membrane-cytoskeletal remodeling
Diet modulation of T cell membrane-cytoskeletal remodeling
Methionine Tolerance Experiment
NIH Proposed Program Project Grant (P01)
Human Metabolism of Ornithine Phenylacetate
Ellagi- and Gallotannins and Their Intestinal Microbial Metabolites in Preventing Gastro-Intestinal Inflammation: A Pharmacometric Approach
Determination of the Optimal Infusion Rate of Amino Acids in Seriously Ill Patients
Protein Requirements and the Effects of Chemotherapy on Protein Digestion and Absorption Capacity in Patients with Pancreatic Cancer
Investigating the Effects of Structured Yangsaeng Exercise Program in Sedentary Older Adults (PESCA)
BL20 CSA - Evaluation of AN777 on Lean Body Mass in Healthy Older Subjects During Bed Rest and Recovery
Integrated Health Sciences Core
Mechanisms of Sarcopenia in Cirrhosis
Metabolic Effects of Chemotherapy and the Clinical Effects of Nutritional Intervention in Cancer
Testing for Citruline in Samples Provided by Henry Jackson Foundation for the Advancement of Military Medicine, Inc
Arginine Metabolism in Older Adults
A Randomized Double Blinded Controlled Trial of an Oral Nutritional Supplement Containing AN 777 in Older Hospitalized Patients
Tryptophan Enriched Diets to Improve the Mood and Cognitive Function of Multiple Sclerosis Patients
Testing for Citruline in Samples Provided by Henry Jackson Foundation for the Advancement of Military Medicine, Inc
Development of Reversed Sepsis Pig Model
Effect of Enteral Nutritional Intervention on Glutathione Metabolism during Pseudomonas Aeruginosa Induced Sepsis in the Pig
Editorship: ESPEN Clinical Nutrition
Eicosapentaenoic Acid and Protein Modulation to Induce Anabolism in COPD
EPA and Protein Modulation in COPD
Optimal Amino Acid Nutrition in Sepsis
AWARDS
ESPEN Followship. Effect of enteral nutritional intervention on glutathione metabolism during Pseudomonas aeruginosa induced sepsis in the pig. (2013)
EDITORSHIPS
Editorial Board Member. American Journal of Physiology: Endocrinology and Metabolism (2008)
Editor. Clinical Nutrition (2005)
Associate Editor. Clinical Nutrition Experimental (2014)
Editor. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism; (2005)