Directory » MARIELLE ENGELEN
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MARIELLE ENGELEN
Co-director Center for Translational Research on Aging and Longevity
Experience : Dr. Marielle Engelen, PhD, Professor and Chancellor EDGES fellow, currently serves as Co-Director and Head of Clinical Research for the Center for Translational Research in Aging and Longevity (CTRAL). She is an expert in the field of clinical nutrition and metabolism in relation to functional performance during aging and in chronic (wasting) diseases. Her research focuses on the metabolic alterations underlying muscle wasting and dysfunction (weakness/fatigue) in chronic diseases, involving the use of stable isotope methodologies, and the effects of nutritional intervention and exercise rehabilitation to restore metabolism and physical and cognitive performance in these patients. As such, she has conducted and supervised many acute studies and coordinating human clinical trials, examining the effects of protein and amino acid intervention in relation to aging and in patients with chronic wasting diseases (i.e., chronic obstructive pulmonary disease, cancer, cystic fibrosis, chronic heart failure, obstructive sleep apnea, cognitive impairment). In addition, she has the expertise in methodology and techniques to examine body composition, muscle function, physical performance, gut and cognitive function, balance, physical activity, wellbeing and clinical outcomes. She is the section editor "Translational Research in Wasting Disease" of the Current Opinion in Clinical Nutrition and Metabolism, and Associate editor for Clinical Nutrition-ESPEN.
Education: Dr. Engelen studied Health Sciences (Movement Sciences) at Maastricht University, Maastricht, the Netherlands. In 1994, she worked as Research Associate at the Dept. of Respiratory and Critical Care Medicine at Harbor UCLA Medical Center, Torrance, CA. After she returned to the Netherlands, she worked as a PhD student at the Dept. of Respiratory Medicine at the Academic Hospital Maastricht and obtained her PhD in 2000 (title thesis: "Muscle wasting in COPD: a metabolic and functional perspective"), and subsequently worked as a postdoctoral fellow at the Dept of Surgery. From 2006 to 2012, she worked as Assistant/ Associate Professor at the Department of Geriatrics, University Arkansas for Medical Sciences and Arkansas Children's Hospital. Learn more about Dr. Engelen by visiting CTRAL's website
Education: Dr. Engelen studied Health Sciences (Movement Sciences) at Maastricht University, Maastricht, the Netherlands. In 1994, she worked as Research Associate at the Dept. of Respiratory and Critical Care Medicine at Harbor UCLA Medical Center, Torrance, CA. After she returned to the Netherlands, she worked as a PhD student at the Dept. of Respiratory Medicine at the Academic Hospital Maastricht and obtained her PhD in 2000 (title thesis: "Muscle wasting in COPD: a metabolic and functional perspective"), and subsequently worked as a postdoctoral fellow at the Dept of Surgery. From 2006 to 2012, she worked as Assistant/ Associate Professor at the Department of Geriatrics, University Arkansas for Medical Sciences and Arkansas Children's Hospital. Learn more about Dr. Engelen by visiting CTRAL's website
COURSES TAUGHT
KINE482. SEMINAR IN KINESIOLOGY
2017A
KINE491. RESEARCH
2020C,2020A,2019C,2019A,2018C
KINE601. RDG RSCH PUBL IN KINE
2020C,2019C
KINE 651. METH HUM CLIN RSCH
Spring 2021/2022
KINE 652. METH HUM CLIN RSCH
Fall 2020/2021
KINE681. SEMINAR
2020C,2017A,2016C
KINE682. SEMINAR IN
2018C,2018A,2017C,2015C
KINE685. DIRECTED STUDIES
2020B,2020A,2019A,2018C,2018B
KINE689. SPECIAL TOPICS IN
2020C,2019C,2019A,2018C,2018A
SELECTED PUBLICATIONS
Journal Articles
Azbell J., *Park J.K., Chang S.H., Engelen M.P.K.J., Park H. Plantar or Palmar Tactile Augmentation Improves Lateral Postural Balance with Significant Influence from Cognitive Load. IEEE in Transactions on Neural Systems & Rehabilitation Engineering 2020: In press [published with student]
Cross K.M., *Granados J.Z., Ten Have G.A.M., Thaden J.J., Engelen M.P.K.J., Lightfoot J.T., Nicolaas E.P. Deutz. Protein fractional synthesis rates within tissues of high- and low-active mice. PLOS One 2020: In press [published with student]
Cruthirds C.L., Deutz N.E.P. , Ligthart-Melis G.C., Simbo S.Y., Engelen M.P.K.J. Walking exercise alters gut function and whole body protein kinetics in COPD patients. Journal Applied Physiology 2020: In press [published with student]
Cruthirds C.L., van der Meij, B.S., *Wierzchowska-McNew A., Deutz N.E.P., Engelen M.P.K.J. Presence or absence of skeletal muscle dysfunction in Chronic Obstructive Pulmonary Disease is associated with distinct phenotypes. Archivos de Bronconeumologia 2020: In press [published with student]
Engelen M.P.K.J., *Jonker R., Thaden J.J., Ten Have G.A.M., *Jeon M.S., Dasarathy S., Deutz N.E.P. Comprehensive metabolic flux analysis to explain muscle weakness in patients with Chronic Obstructive Pulmonary Disease. Clinical Nutrition 2020: 10: 3056-306 [published with student]
Granados J.Z., Ten Have G.A.M., *Letsinger A.C., Thaden J.J., Engelen M.P.K.J., Lightfoot J.T., Deutz N.E.P. Whole-Body Arginine Pathway is Activated in High-Active Mice. PLOS One 2020: In press [published with student]
Kirschner S.K., Deutz N.E.P., *Jonker R., Olde Damink S.W.M, Harrykissoon R.I., Zachria A.J., Engelen M.P.K.J.. Small intestinal dysfunction attenuates protein digestion and absorption and anabolic response to feeding in patients with Chronic Obstructive Pulmonary Disease. Clinical Nutrition 2020: In press [published with student]
Ligthart-Melis G.C, Engelen M.P.K.J., Simbo S.S., Ten Have G.A.M., Thaden J.J., Cynober L., Deutz N.E.P. Metabolic Consequences of Supplemented Methionine in a Clinical Context. J Nutrition 2020: 150:2538S-2547S
Park J.K., Deutz N.E.P., *Cruthirds C.L., *Kirschner S.K., Park H., Madigan M.L., Engelen M.P.K.J. Risk Factors for postural and functional balance impairment in Chronic Obstructive Pulmonary Disease. Journal Clinical Medicine. 2020: 9: 609 [published with student]
Pichard C., Engelen M.P.K.J. Editorial: Energy needs: quick and easy to measure. Current Opinion in Clinical Nutrition & Metabolic Care. 2020: 3:155-156
Van der Meij B.S., Deutz N.E.P., Olde Damink S.O., Rodriguez R.E.R., Engelen M.P.K.J. Early signs of impaired gut function affect daily functioning in patients with advanced cancer undergoing chemotherapy. Journal Parenteral Enteral Nutrition 2020: In press
Engelen M.P.K.J., Pichard C. Editorial: Crosstalk between organs and multimodal therapeutic approaches: new insights. Current Opinion in Clinical Nutrition & Metabolic Care. 2019: 22(3): 183-184
Engelen M.P.K.J., Ten Have G.A.M., Thaden J.J., Deutz N.E.P. New advances in stable isotope dilution methods to assess whole body protein and amino acid metabolism. Current Opinion in Clinical Nutrition & Metabolic Care. 2019: 22(5): 337-346
Jonker R, Deutz N.E.P., Ligthart-Melis G.C., Zachria A.J., Veley E.A., Harrykissoon R., Engelen M.P.K.J. Preserved anabolic threshold and capacity as estimated by a novel stable tracer approach suggests no anabolic resistance or increased requirements in weight stable COPD patients. Clinical Nutrition 2019: 38 (4) 1833-1843 [published with student]
Jonker R., Deutz N.E.P., Schols A.M.W.J., Veley E.A., Harrykissoon R., Zachria A.J., Engelen M.P.K.J. Whole body protein anabolism in COPD patients and healthy older adults is not enhanced by adding either carbohydrates or leucine to a serving of protein. Clinical Nutrition 2019: 38 (4): 1684-1691 [published with student]
Ten Have G.A.M., Engelen M.P.K.J., Wolfe R.R., Deutz N.E.P. Inhibition of jejunal protein synthesis and breakdown in Pseudomonas aeruginosa induced sepsis pig model. American Journal Physiology 2019: 316 (6): G755-G762
Van der Meij B.S., *De Groot L.M., Deutz N.E.P., Engelen M.P.K.J. Effects of acute oral feeding on protein metabolism and muscle protein synthesis in people with cancer. Nutrition 2019: 11;67-68 [published with student]
Van der Meij B.S., Deutz N.E.P., Rodriguez R., Engelen M.P.K.J. Increased amino acid turnover and myofibrillar protein breakdown in advanced cancer are associated with muscle weakness and impaired physical function. Clinical Nutrition 2019
Van der Meij B.S., Teleni L, Engelen M.P.K.J., Deutz N.E.P. Amino Acid Kinetics and the Response to Nutrition in Patients with Cancer. International Journal of Radiation Biology 2019: 95 (4):480-492 [published with student]
De Betue C.T.I., Garcia Casal X.C., van Waardenburg D.A., Schexnayder S.M., Joosten K.F.M., Deutz N.E.P., Engelen M.P.K.J. 24-Hour protein, arginine and citrulline metabolism in fed critically ill children - a stable isotope tracer study. Clinical Nutrition. 2017: 36:876-887 [published with student]
Deutz N.E.P., Simbo S.Y., Ligthart-Melis G.C., Cynober C., Smriga N., Engelen M.P.K.J. Tolerance to increased supplemented dietary intake levels of methionine in healthy older adults. American Journal Clinical Nutrition 2017: 106:675-683
Engelen M.P.K.J., Klimberg V.S., Allasia A, Deutz N.E.P. Presence of early stage cancer does not impair the early protein metabolic response to major surgery. Journal of Cachexia, Sarcopenia and Muscle. 2017: 8:447-456
Jonker R., Deutz N.E.P., Erbland M.L., Anderson P.J., Engelen M.P.K.J. Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults. Metabolism 2017: 69:120-129 [published with student]
Kumar A., Davuluri G., Nascimento R., Engelen M.P.K.J. , Ten Have G.A.M., Deutz N.E.P., Dasarathy S. Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis. Hepatology 2017: 65:2045-58
Mason A, Engelen M.P.K.J., Ivanov I, Toffolo G.M., Deutz N.E.P. A Four Compartments Compartmental Model to Assess Net Whole Body Protein Breakdown Using a Pulse of Phenylalanine and Tyrosine Stable Isotopes in Humans. Am J Physiol 2017: 313:E63-74 [published with student]
Ten Have G.A.M., Deutz R.C.I., Engelen M.P.K.J., Wolfe R.R., Deutz N.E.P. Characteristics of a Pseudomonas aeruginosa induced porcine sepsis model for multi-organ metabolic flux measurements. Laboratory animals 2017:23677217718003. Epub 2017/07/07. doi: 10.1177/0023677217718003. PubMed PMID: 28679339. [published with student]
Ten Have G.A.M., Engelen M.P.K.J., Wolfe R.R., Deutz N.E.P. Phenylalanine isotope pulse method to measure effect of sepsis on protein breakdown and membrane transport in the pig. Am J Physiol 2017: 312:E519-529
Walker D.K., Thaden J.J., Wierzchowska - McNew A., Engelen M.P.K.J., Deutz N.E.P. Determination of beta-Hydroxy-beta-methylbutyrate Concentration and Enrichment in Human Plasma Using Chemical Ionization Gas Chromatography Tandem Mass Spectrometry. Journal of Chromatography B. 2017;1040:233-238
Engelen MP, Safar AM, Bartter T, Koeman F, Deutz NE. Reduced arginine availability and nitric oxide synthesis in cancer is related to impaired endogenous arginine synthesis. Clinical Science. 2016. Doi: 10.1042/cs20160233
Engelen MP, van der Meij BS, Deutz NE. Protein anabolic resistance in cancer: does it really exist? Curr Opin Clin Nutr Metab Care. 2016;19(1):39-47. doi: 10.1097/MCO.0000000000000236. PubMed PMID: 26560520
Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease. Am J Clin Nutr. 2016. doi: 10.3945/ajcn.115.125187. PubMed PMID: 27146652
Engelen MP, Safar AM, Bartter T, Koeman F, Deutz NE. High anabolic potential of essential amino acid mixtures in advanced nonsmall cell lung cancer. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 2015;26(9):1960-6. doi: 10.1093/annonc/mdv271. PubMed PMID: 26113648; PMCID: PMC4551158
Ligthart-Melis GC, Marini JC, Engelen MP, Deutz NE. Glutamine supplementation, citrulline production, and de novo arginine synthesis: is there a relation? The American Journal of Clinical Nutrition. 2015;101(4):890-2. doi: 10.3945/ajcn.114.104679.
Tsien C, Davuluri G, Singh D, Allawy A, Ten Have GA, Thapaliya S, Schulze JM, Barnes D, McCullough AJ, Engelen MP, Deutz NE, Dasarathy S. Metabolic and molecular responses to leucine enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis. Hepatology (Baltimore, Md. 2015. doi: 10.1002/hep.27717. PubMed PMID: 25613922.
Engelen MP, Com G, Deutz NE. Increased whole body hydroxyproline production as assessed by a new stable isotope technique is associated with hip and spine bone mineral loss in cystic fibrosis. Clin Nutr. 2014;33(6):1117-21. doi: 10.1016/j.clnu.2013.12.008. PubMed PMID: 24423745.
Engelen M.P.K.J. Com G., Anderson P.J., Deutz N.E.P. New Stable Isotope Method to Measure Protein Digestibility and Response to Pancreatic Enzyme Intake in Cystic Fibrosis, Clin. Nutr. 2014, 33: 1024-32
Engelen MPKJ, Com G, Deutz NEP. Protein is an important but undervalued macronutrient in the nutritional care of patients with cystic fibrosis. Current Opinion in Clinical Nutrition & Metabolic Care. 2014;17 (6), 515-520. Publish Ahead of Print:10.1097/MCO.0000000000000100.
Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Hydrolyzed casein and whey protein meals comparably stimulate net whole-body protein synthesis in COPD patients with nutritional depletion without an additional effect of leucine co-ingestion. Clin Nutr. 2014;33(2):211-20. doi: 10.1016/j.clnu.2013.06.014. PubMed PMID: 23886411; PubMed Central PMCID: PMC3883994. [published with student]
Engelen MP, Com G, Luiking YC, Deutz NE. Stimulated nitric oxide production and arginine deficiency in children with cystic fibrosis with nutritional failure. The Journal of pediatrics. 2013;163(2):369-75
Engelen M.P.K.J., Com G., Wolfe R.R., Deutz N.E.P. Dietary essential amino acids are highly anabolic in pediatric patients with Cystic Fibrosis. J. Cystic Fibrosis. 2013:12: 45[8211]453
Engelen, M. P., De Castro, C. L., Rutten, E. P., Wouters, E. F., Schols, A. M., & Deutz, N. E. (2012). Enhanced anabolic response to milk protein sip feeding in elderly subjects with COPD is associated with a reduced splanchnic extraction of multiple amino acids. Clin Nutr, 31(5), 616-624 [published with student]
Engelen, M. P., Rutten, E. P., De Castro, C. L., Wouters, E. F., Schols, A. M., & Deutz, N. E. (2012). Casein protein results in higher prandial and exercise induced whole body protein anabolism than whey protein in chronic obstructive pulmonary disease. Metabolism, 61(9), 1289-1300 [published with student]
Engelen, M. P., Schroder, R., Van der Hoorn, K., Deutz, N. E., & Com, G. (2012). Use of body mass index percentile to identify fat-free mass depletion in children with cystic fibrosis. Clin Nutr [published with student]
Jonker, R., Engelen, M. P., & Deutz, N. E. (2012). Role of specific dietary amino acids in clinical conditions. Br J Nutr, 108 Suppl 2(S2), S139-148 [published with student]
Ten Have, G. A., Engelen, M. P., Soeters, P. B., & Deutz, N. E. (2012). Absence of post-prandial gut anabolism after intake of a low quality protein meal. Clin Nutr, 31(2), 273-282
RESEARCH PROJECTS
A Longitudinal Investigation of the Cerebellum in Adulthood: Anatomical and Network Changes, Motor Function, and Cognition
Mechanisms of motor impairments with obesity in males and females
Targeted nutritional approach to improve muscle function and physical activity by restoring metabolic deregulations during recovery from sepsis
Nutritional Modulation to Minimize Resistance Exercise Induced Metabolic Deregulations and Improve Training Responsiveness in Chronic Obstructive Pulmonary Disease
Persistent Readiness through Early Prediction (PREP)
Targeted nutritional approach to improve muscle function and physical activity by restoring metabolic deregulations during recovery from sepsis
Targeted nutritional modulation to reduce intrinsic and exercise induced metabolic deregulations, and improve training responsiveness in Chronic Obstructive Pulmonary Disease with muscle dysfunction
Targeted nutritional modulation to reduce intrinsic and exercise induced metabolic deregulations, and improve training responsiveness in Chronic Obstructive Pulmonary Disease with muscle dysfunction
A longitudinal investigation of the cerebellum in adulthood: anatomical and network changes, motor function, and cognition
Improvement of Metabolism and Outcome by [223]-hydroxy [223]-methylbutyric (HMB) with Essential Amino Acid (EAA) Nutritional Supplementation in Sepsis
Targeted Nutritional Modulation to Reduce Intrinsic and Exercise Induced Metabolic Deregulations, and Improve Training Responsiveness in Chronic Obstructive Pulmonary Disease with Muscle Dysfunction
Mechanisms of Motor Function Impairments with Obesity and Advanced Age
Enhancing Quality of Life of Aged Horses: Delineating the Progression of Aging in Equine Skeletal Muscle
Identify the Metabolic Mechanisms and Systemic Factors Underlying Skeletal Muscle Dysfunction in COPD Patients with Abdominal Obesity and the Impact of Coexisting Sarcopenia
Nutritional modulation to minimize resistance exercise induced metabolic deregulations and improve training responsiveness in Chronic Obstructive Pulmonary Disease
Optimal Beta-Hydroxy-Beta-Methylbutyrate (HMB) with Essential Amino Acid (EAA) Nutritional Supplementation in Sepsis
IBM Sensor Testing
Nutritional modulation to minimize resistance exercise induced metabolic deregulations and improve training responsiveness in Chronic Obstructive Pulmonary Disease
Effects of Low Fose of Fish Oil (EPA+DHA) vs. combined EPA+DHA and HMB or Curcumin Supplementation on Protein Metabolism, Muscle Mass and Functional Capacity in Moderate to Severe COPD
Role of Metabolic Phenotyping, Changes in Gut Function and the Response to a Meal to Explain the Variability in Weight Loss induced by Very Low Caloric Diet in (Morbidly) Obese Adults
PESCA: Intramuscular Metabolic Phenotyping to Identify Muscle Dysfunction in Older Adults with Chronic Disease
Catapult Round 3 - Linking Metabolic Phenotype to Mood and Neurocognitive Functions in Autism Spectrum Disorder (Funded amount $30,000)
ESPEN Research Fellowships
Human Metabolism of HMB
Feasibility of Novel Laboratory Methods for use in Nutrition Studies
The Effects of Acute Resistance Exercise on Protein and Amino Acid Metabolism in Chronic Obstructive Pulmonary Disease
Clinical Science and Translational Research (CSTR) Institute
Diet modulation of T cell membrane-cytoskeletal remodeling
Diet modulation of T cell membrane-cytoskeletal remodeling
Methionine Tolerance Experiment
Human Metabolism of Ornithine Phenylacetate
Determination of the Optimal Infusion Rate of Amino Acids in Seriously Ill Patients
BL20 CSA - Evaluation of AN777 on Lean Body Mass in Healthy Older Subjects During Bed Rest and Recovery
Metabolic Effects of Chemotherapy and the Clinical Effects of Nutritional Intervention in Cancer
A Randomized Double Blinded Controlled Trial of an Oral Nutritional Supplement Containing AN 777 in Older Hospitalized Patients
Editorship: ESPEN Clinical Nutrition
Eicosapentaenoic Acid and Protein Modulation to Induce Anabolism in COPD
EPA and Protein Modulation in COPD
Longitudinal Assessment of Fat Free Mass Index and its impact on Lung Health and Overall Health Metrics in Pediatric Patients with Cystic Fibrosis
Optimal Amino Acid Nutrition in Sepsis
EDITORSHIPS
Section editor. Translational research in wasting diseases. Current Opinion Clinical Nutrition Metabolic Care
Associate Editor. Clinical Nutrition & Clinical Nutrition-ESPEN
LEADERSHIP POSITIONS
Co-Director CTRAL
Head Clinical Research CTRAL
Head Clinical Research CTRAL
Director. Weekly Journal club meeting Center for Translational research on Aging and Longevity, TAMU
OTHER NOTED ACCOMPLISHMENTS
Chancellor EDGES fellow