JAMES FLUCKEY

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jfluckey@tamu.edu

313 GGB

428D EDCT

JAMES FLUCKEY

Interim Associate Dean and Professor

KINESIOLOGY AND SPORT MANAGEMENT

Curriculum Vitae

Education

Ph.D., Physiology, Pennsylvania State University (1995)

M.S., Exercise Physiology, Ball State University (1992)

B.S., Health and Physical Education, Eastern New Mexico University (1990)

COURSES TAUGHT

KINE386. SPORT PHYSIOLOGY

2016C,2015C

KINE433. Physiology Of Exercise

2009B,2008B,2007C,2006C,2006B

KINE433. PHYSIOLOGY OF EXERCISE

2020C,2020B,2019C,2019B,2018B

KINE485. DIRECTED STUDIES

2018A,2017A,2015B,2014B

KINE485. Directed Studies

2009A,2008C,2008A,2007C,2007B

KINE491. Research

2009B,2009A,2008C,2008B,2008A

KINE491. RESEARCH

2020A,2019C,2019A,2018C,2018B

KINE637. Exercise Physiology

2009A,2008A,2007A

KINE637. EXERCISE PHYSIOLOGY

2020A,2019A,2018A,2017A,2016A

KINE647. INST & TECH EX PHYS I

2020A,2019A,2018A,2017A,2016A

KINE681. SEMINAR

2019A,2015C

KINE681. Seminar

2007A

KINE682. Seminar In

2009B,2009A,2008B,2006C,2006A

KINE682. SEMINAR IN

2020C,2019C,2017A,2016A,2012C

KINE683. PRACTICUM IN KINESIOLOGY

2015B

KINE684. PROF INTERNSHIP

2020B,2017C,2016A,2015C,2015A

KINE684. Professional Internship

2009B,2009A,2008B,2007C,2006C

KINE685. DIRECTED STUDIES

2020C,2020B,2020A,2019B,2019A

KINE685. Directed Studies

2009B,2009A,2008C,2008B,2008A

FORMER DOCTORAL STUDENTS

Colleen Louise O'Reilly, Ph.D. (Spring 2022)

Jessica Marie Cardin, Ph.D. (Fall 2021)

John Williams Deaver, Ph.D. (Fall 2020)

Chelsea Goodliffe Goodenough (Summer 2019)

Amanda Renee Davis (Spring 2017)

Kevin Lee Shimkus (Fall 2016)

Michael Wiggs (Summer 2011)

Mats Inge Nilsson (Fall 2009)

Heath G. Gasier (Spring 2009)

SELECTED PUBLICATIONS

Journal Articles

Kuczmarski JM, Hord JM, Lee Y, Guzzoni V, Rodriguez D, Lawler MS, Garcia-Villatoro EL, Holly D, Ryan P, Falcon K, Garcia M, Janini Gomes M, Fluckey JD, Lawler JM. Effect of Eukarion-134 on Akt-mTOR signalling in the rat soleus during 7 days of mechanical unloading. Exp Physiol. 2018 Apr 1;103(4):545-558. doi: 10.1113/EP086649. Epub 2018 Feb 28. PMID: 29315934 Secondary

Shimkus KL, Shirazi-Fard Y, Wiggs MP, Ullah ST, Pohlenz C, Gatlin DM 3rd, Carroll CC, Hogan HA, Fluckey JD. J Appl Physiol (1985). RESPONSES OF SKELETAL MUSCLE SIZE AND ANABOLISM ARE REPRODUCIBLE WITH MULTIPLE PERIODS OF UNLOADING/RELOADING. 2018 Aug 9. doi: 10.1152/japplphysiol.00736.2017.

C. A. Phillips, C. A. Cavinder, D. H. Sigler, and J. D. Fluckey. Effect of various levels of dietary starch on glycogen replenishment in the light working horse.The Professional Animal Scientist 33:729[48]13738 (2017). https://doi.org/10.15232/pas.2017-01651

Kuczmarski JM, JM Hord, Y Lee, V Guzzoni, D Rodriguez, MS Lawler, EE Garcia-Villatoro, D Holly, P Ryan, K Falcon, M Garcia, JD Fluckey, JM Lawler. EUK-134 modulates anabolic signaling in the rat soleus after 7 days of hindlimb unloading. Experimental Physiology. In Press, December 2017.

Mark S.Katsma, Shivam H.Patel, Erica Eldon, Kathryn A.Corbell, Kevin L.Shimkus, James D.Fluckey, Chad C.Carroll. The influence of chronic IL-6 exposure, in vivo, on rat Achilles tendon extracellular matrix. Cytokine 93: 10-14, 2017. https://doi.org/10.1016/j.cyto.2017.04.011

Yang Lee, James D. Fluckey, Sanjukta Chakraborty and Mariappan Muthuchamy. Hyperglycemia- and hyperinsulinemia-induced insulin resistance causes alterations in cellular bioenergetics and activation of inflammatory signaling in lymphatic muscle. FASEB J. 2017 Jul;31(7):2744-2759. doi: 10.1096/fj.201600887R. Epub 2017 Mar 15. PMID: 28298335

Brown JL, Rosa-Caldwell ME, Lee DE, Brown LA, Perry RA, Shimkus KL, Blackwell TA, Fluckey JD, Carson JA, Dridi S, Washington TA, Greene NP. PGC-1[224][224]3B14 gene expression is suppressed by the IL-6-MEK-ERK 1/2 MAPK signalling axis and altered by resistance exercise, obesity and muscle injury. Acta Physiol (Oxf). 2016 Nov 3. doi: 10.1111/apha.12826. [Epub ahead of print] PMID: 27809412

Cover Image, Volume 117, Number 8, August 2016. Lee DE, Brown JL, Rosa ME, Brown LA, Perry RA Jr, Wiggs MP, Nilsson MI, Crouse SF, Fluckey JD, Washington TA, Greene NP. J Cell Biochem. 2016 Aug;117(8):i. doi: 10.1002/jcb.25630. PMID: 27301891

Galvan E, Walker D, Simbo S, Dalton R, Levers K, O[48]19Connor A, Goodenough C, Barringer N, Greenwood M, Christopher Rasmussen C, Smith S, Riechman S, Fluckey J, Murano P, Earnest C, Kreider R. Acute and Chronic Safety and Efficacy of Dose Dependent Creatine Nitrate Supplementation and Exercise Performance. Journal of the International Society of Sports Nutrition. 12:12, 2016

Lee, D.L., Brown, J.L., Rosa, M.E., Brown, L.A., Perry, R.A., Wiggs, M.P., Nilsson, M.I., Crouse, S.F., Fluckey, J.D., Washington, T. A. & Greene, N.P. (2016). microRNA-16 is downregulated during insulin resistance and controls skeletal muscle protein accretion. Journal of Cellular Biochemistry, 117, 1775-1787.

Macias BR, Lima F, Swift JM, Shirazi-Fard Y, Greene ES, Allen MR, Fluckey J, Hogan HA, Braby L, Wang S, Bloomfield SA. Simulating the Lunar environment: Partial weightbearing and high-LET radiation induce bone loss and increase sclerostin-positive osteocytes. Radiat Res 186: 254-263, 2016

Simmons, EE, JD Fluckey, SE Riechman. Cumulative Muscle Protein Synthesis and Protein Intake Requirements Annual Review of Nutrition 36(1) [183][183] August 2016

Fluckey JD, BS Lambert, NP Greene, KL Shimkus, JM Cardin, SE Riechman, SF Crouse. Reply to letter to the editor: to D2O or not to D2O? What are the reasons we D2O it at all? AJP-Endo Metab. 308:928-931, 2015.

Lambert BS, KL Shimkus, JD Fluckey, SE Riechman, NP Greene, JM Cardin, SF Crouse. Anabolic responses to acute and chronic resistance exercise are enhanced when combined with aquatic treadmill exercise. AJP-Endo Metab. 308(3):192-200, 2015.

microRNA[48]1016 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion. David E Lee, Jacob L Brown, Megan E Rosa, Lemuel A Brown, Richard A Perry, Michael P Wiggs, Mats I Nilsson, Stephen F Crouse, James D Fluckey, Tyrone A Washington, Nicholas P Greene. Journal of Cellular Biochemistry, 2015

Partial Support Ventilation and Mitochondrial-Targeted Antioxidants Protect against Ventilator-Induced Decreases in Diaphragm Muscle Protein Synthesis. Matthew B Hudson, Ashley J Smuder, W Bradley Nelson, Michael P Wiggs, Kevin L Shimkus, James D Fluckey, Hazel H Szeto, Scott K Powers. PloS one, 2015.

Greene NP, Nilsson MI, Washington TA, Lee DE, Brown LA, Papineau AM, Shimkus KL, Greene ES, Crouse SF, Fluckey JD. Impaired exercise-induced mitochondrial biogenesis in the obese Zucker rat, despite PGC-1 alpha induction, is due to compromised mitochondrial translation elongation. Am. J. Physiol. - Endocrin and Metab. 306:E503-E511, 2014

Kresta JY, Oliver JM, Jagim AR, Fluckey J, Riechman S, Kelly K, Meininger C, Mertens-Talcott SU, Rasmussen C, Kreider RB. Effects of 28 days of beta-alanine and creatine supplementation on muscle carnosine, body composition and exercise performance in recreationally active females. J Int Soc Sports Nutr. 2014 Nov 30;11(1):55. doi: 10.1186/s12970-014-0055-6

Lambert, B.S., Greene, N.P., Carradine, A.T., Joubert, D.P., Fluckey, J.D., Riechman, S.E., & Crouse, S.F. (2014). Aquatic treadmill training reduces blood pressure reactivity to physical stress. Medicine and Science in Sports and Exercise, 46, 809-816

Oliver JM, Jagim AR, Pischel I, Jager R, Purpura M, Sanchez A, Fluckey J, Riechman S, Greenwood M, Kelly K, Meininger C, Rasmussen C, Kreider, RB. Effects of short-term ingestion of Russian Tarragon prior to creatine monohydrate supplementation on whole body and muscle creatine retention and anaerobic. JISSN 11: article 6, 2014

Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity. Nilsson MI, Dobson JP, Greene NP, Wiggs MP, Shimkus KL, Wudeck EV, Davis AR, Laureano ML, Fluckey JD. FASEB J. 2013

Carter JG, Fluckey J, Brooks KA, Greenwood M. Metabolism and Supplementation: A systematic review on anaerobic energy metabolism and supplementation to improve performance by limiting the effects of blood lactate. Journal of Sports and Human Performance. 1(3): 50-70

Oliver, J.M., Jagim, A.R., Sanchez, A.C., Mardock, M.A., Kelly, K. A.; Meredith, H. J., Smith, G. L., Greenwood, M., Parker, J. L., Riechman, S. E., Fluckey, J.D., Crouse, S. F., & Kreider, R.B. (2013) Greater gains in strength and power with intra-set rest intervals in hypertrophic training. Journal of Strength and Conditioning Research, 27, 3116-3131

Greene, N.P., Fluckey, J.D., Lambert, B.S., Greene, E.S., Riechman, S.D., & Crouse S.F. (2012) Regulators of Blood Lipids and Lipoproteins? PPAR3B4 and AMPK, Induced by Exercise, are Correlated with Lipids and Lipoproteins in Overweight/Obese Men and Women. American Journal of Physiology - Endocrinology Metabolism

Jagim AR, Oliver JM, Sanchez A, Galvan E, Fluckey J, Riechman S, Greenwood M, Kelly K, Meininger C, Rasmussen C, Kreider RB. A buffered form of creatine does not promote greater changes in muscle creatine content, body composition, or training adaptations than creatine monohydrate. Journal of the International Society of Sports Nutrition. 9:43. 2012

Regulators of blood lipids and lipoproteins? PPAR3B4 and AMPK, induced by exercise, are correlated with lipids and lipoproteins in overweight/obese men and women. Greene NP, Fluckey JD, Lambert BS, Greene ES, Riechman SE, Crouse SF. Am J Physiol Endocrinol Metab. 2012 Nov 15;303(10):E1212-21

Acute resistance exercise augments integrative myofibrillar protein synthesis Heath G. Gasier, James D. Fluckey, Stephen F. Previs, Michael P. Wiggs, Steven E. Riechman Metabolism Clinical and Experimental 2011

Cumulative responses of muscle protein synthesis are augmented with chronic resistance exercise training. Gasier HG. Riechman SE. Wiggs MP. Buentello A. Previs SF. Fluckey JD. Acta Physiologica. 201(3):381-9, 2011

Gasier HG, Fluckey JD, Previs SF, Wiggs MP, Riechman SE. Acute resistance exercise augments integrative myofibrillar protein synthesis. Metabolism, 2011. Epub ahead of print. PMID: 21864869

Gasier HG, Fluckey JD and Previs SF. The application of 2H2O to measure skeletal muscle protein synthesis. Nutr Metab (Lond) 7: 31, 2010

Gasier HG, SE Riechman, MP Wiggs, A Buentello, SF Previs and JD Fluckey. Cumulative responses of muscle protein synthesis are augmented with chronic resistance exercise training. Acta Physiologica, In Press, 2010

Nilsson MI, Greene NP, Dobson JP, Wiggs MP, Gasier HG, Macias BR, Shimkus KL and Fluckey JD. Insulin resistance syndrome blunts the mitochondrial anabolic response following resistance exercise. Am J Physiol Endocrinol Metab

Swift JM, Gasier HG, Swift SN, Wiggs, MP, Hogan HA, Fluckey JD and Bloomfield SA. Increased training loads do not magnify cancellous bone gains with rodent jump resistance exercise. J Appl Physiol, 109: 1600-7, 2010

Norrbrand L, JD Fluckey, M Pozzo, PA Tesch. Eccentric overload appears necessary to optimize skeletal muscle adaptations to chronic resistance exercise. Eur J Appl Physol 102:271-281, epub 2007.

Dupont-Versteegden EE, BA Strotman, CM Gurley, D Gaddy, M Knox, JD Fluckey, and Peterson CA. Nuclear translocation of EndoG at the initiation of disuse muscle atrophy and apoptosis is specific to myonuclei. Am J Physiol Regul Integr Comp Physiol. 291(6):R1730-40, 2006.

Dupont-Versteegden EE, JD Fluckey, M Knox, D Gaddy, and CA Peterson. The effect of flywheel-based resistance exercise on processes contributing to muscle atrophy during unloading in adult rats. J. Appl. Physiol. 101:202-12, 2006.

Fluckey JD, M Knox, LM Smith, EE Dupont-Versteegden, D Gaddy, PA Tesch, and CA Peterson. The insulin-facilitated increase of muscle protein synthesis after resistance exercise involves a MAP-kinase pathway. Am. J. Physiol - Endocrinol.& Metab. 290:E1205-11, 2006.

Hays NP, RD Starling, DH Sullivan, JD Fluckey, RH Coker, and WJ Evans. Comparison of insulin sensitivity assessment indices with euglycemic-hyperinsulinemic clamp data following a dietary and exercise intervention in older adults. Metab.: Clin. and Exp. 55: 525-532, 2006.

Hays NP, RD Starling, DH Sullivan, JD Fluckey, RH Coker, RH Williams, JA Carrithers and WJ Evans. Effects of an ad libitum high carbohydrate diet and aerobic exercise training on insulin action and muscle metabolism in older men and women. J. Gerontol.: Biol. Sci. and Med. Sci.: 61A(3):299-304, 2006.

Carroll CC, JD Fluckey, RH Williams, DH Sullivan and TA Trappe. Human soleus and vastus lateralis muscle protein metabolism with an amino acid infusion. Am. J. Physiol - Endocrinol.& Metab. 288: E479-E485, 2005.

Campbell, W.W., Haub, M.D., Fluckey, J.D., Ostlund, R.E., Morse-Carrithers, H., Hulver, M.W., Thyfault, J.P., & Birge, Z.K. (2004). Pinitol supplementation and insulin-mediated glucose metabolism in older humans. Journal of Nutrition, 134, 2998-3003.

Fluckey, J.D., Cortright, R.N., Tapscott, E., Koves, T., Smith, L., Pohnert, S., & Dohm, G.L. (2004). Active involvement of PKC for insulin-mediated rates of muscle protein synthesis. American Journal of Physiology, 286, E753-E758.

Fluckey JD, EE Dupont-Versteegden, M Knox, D Gaddy, PA Tesch and CA Peterson. Insulin facilitation of muscle protein synthesis following resistance exercise in hindlimb suspended rats is independent of a rapamycin-sensitive pathway. Am. J. Physiol. 287: E1070-E1075, 2004.

Hays, N.P., Starling, R.D., Liu, X., Sullivan, D.H., Trappe, T.A., Fluckey, J.D., & Evans, W.J. (2004). Effects of an ad libitum, low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: A randomized control trial. Archives of Internal Medicine, 164, 210-217.

Knox, M., Fluckey, J.D., Peterson, C.A., Bennett, P., Peterson, C.A., & Dupont-Versteegden, E.E. (2004). Hind limb unloading in adult rats using an alternative tail harness design. Aviation & Space Environmental Medicine, 75, 692-696.

Trappe, S., Ballagher, P., Harber, M., Carrithers, J., Fluckey, J.D., & Trappe, T. (2003). Single muscle fiber contractile properties in young and old men and women. Journal of Physiology, 552(1), 47-58.

Wells, A.M., Haub, M.D., Fluckey, J.D., Williams, D.K., Chernoff, R., & Campbell, W.W. (2003). Comparisons of vegetarian and beef-containing diets on hematological indexes and iron stores during a period of resistive training in older men. Journal of the American Dietetic Association, 594-601.

Fluckey, J.D., Dupont-Versteegden, E., Montague, D.C., Knox, M., Peterson, C.A., & Gaddy-Kurten, D. (2002). A rat resistance exercise regimen attenuates losses of musckuloskeletal mass during hindlimb suspension. ACTA Physiology Scandinavia, 174, 293-300.

Fluckey, J.D., Asp, S., Enevoldsen, L.H., & Galbo, H. (2001). Alterations of insulin-mediated muscle protein synthesis in rats after high intensity eccentric exercise. Journal of Clinical Endocrinology & Metabolism, 86(10), 5067-5070.

Trappe, T.A., Fluckey, J.D., White, F., Lambert, C.P., & Evans, W.J. (2001). Skeletal muscle PGF2 and PGE2 in response to eccentric exercise: Influence of ibuprofen and acetaminophen. Journal of Clinical Endocrinology & Metabolism, 86(10), 5067-5070.

Enevoldsen, L.H., Stallknecht, B., Fluckey, J.D., & Galbo, H. (2000). The effect of exercise training on in situ insulin-stimulated glucose uptake in intraabdominal adipose tissue in rats. American Journal of Physiology, 278, E25-E34.

Enevoldsen, L.H., Stallknecht, B., Fluckey, J.D., & Galbo, H. (2000). The effect of exercise training on in vivo epinephrine-stimulated lipolysis in intraabdominal adipose tissue in rats. American Journal of Physiology, 279, E585-E592.

Fluckey, J.D., Pohnert, S.C., Boyd, S.G., Cortright, R.N., Trappe, T.A., & Dohm, G.L. (2000). Insulin stimulation of muscle protein synthesis in obese Zucker rats is not via a rapamycin-sensitive pathway. American Journal of Physiology, 279, E182-E187.

Hernandez, J.M., Moccia, T., Fluckey, J.D., Ulbrecht, J.S., & Farrell, P.A. (2000). Fluid snacks to help persons with insulin-dependent diabetes mellitus avoid late onset post-exercise hypoglycemia. Medicine and Science in Sports and Exercise, 32, 904-910.

Cortright, R.N., Zheng, D., Jones, J.P., Fluckey, J.D., Lowell, B.B., & Dohm, G.L. (1999). The effect of denervation and exercise on UCP-3 gene expression in skeletal muscle. American Journal of Physiology, 276, E217-E221.

Farrell, P.A., Fedele, M.J., Hernandez, J., Fluckey, J.D., Miller, J.L.III., Vary, T.C., Kimball, S.R., & Jefferson, L.S. (1999). Hypertrophy of skeletal muscle in diabetic rats in response to chronic resistance exercise. Journal of Applied Physiology, 87, 1075-1082.

Fluckey, J.D., Ploug, T., & Galbo, H. (1999). Attenuated insulin action on glucose uptake and transport following resistance exercise in rats. ACTA Physiology Scandinavia, 167, 77-82.

Fluckey, J.D., Ploug, T., & Galbo, H. (1999). Mechanisms associated with hypoxia- and contraction- mediated glucose transport are fiber-type dependent. ACTA Physiology Scandinavia, 167, 83-87.

Stallknecht, B., Donsmark, M., Enevoldsen, L.H., Fluckey, J.D., & Galbo, H. (1999). Estimation of rat muscle blood flow by microdialysis perfused with ethanol, C-ethanol, and H2O. Journal of Applied Physiology, 86, 1054-1061.

Westerlind, K.C., Fluckey, J.D., Gordon, S.E., Kraemer, W.J., Farrell, P.A., & Turner, R.T. (1998). Journal of Applied Physiology, 84(2), 459-464.

Brambrink, J.K., Fluckey, J.D., Hickey, M.S., & Craig, B.W. (1997). Influence of mass and work on post-exercise glucose and insulin responses in young untrained subjects. ACTA Physiology Scandinavia, 161(3), 371-377.

Fluckey, J.D., Vary, T.C., Jefferson, L.S., Evans, W.J., & Farrell, P.A. (1996). Insulin stimulation of protein synthesis in rat skeletal muscle following resistance exercise is maintained with advancing age. Journal of Gerontology: Psychological Sciences and Social Sciences, 51A, B323-B330.

Fluckey, J.D., Vary, T.C., Jefferson, L.S., & Farrell, P.A. (1996). Augmented insulin action on rates of protein synthesis following resistance exercise in rats. American Journal of Physiology, 270, E313-E319.

Fluckey, J.D., Kraemer, W.J., & Farrell, P.A. (1995). Pancreatic islet insulin secretion is increased following resistance exercise in rats. Journal of Applied Physiology, 79, 1100-1105.

Fluckey, J.D., Hickey, M.S., Brambrink, J.K., Hart, K.K., Alexander, K., & Craig, B.W. (1994). Effects of resistance exercise on glucose tolerance in normal and glucose intolerant individuals. Journal of Applied Physiology, 77, 1087-1092.

Book Chapters

Gasier HG, Previs SF, Pohlenz C, Fluckey JD, Gatlin DM 3rd, Buentello JA (2009). A novel approach for assessing protein synthesis in channel catfish, Ictalurus punctatus. Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):235-8. Epub 2009 Jun 27.

Gasier HG, Riechman SE, Wiggs MP, Previs SF, Fluckey JD (2009). A comparison of 2H2O and phenylalanine flooding dose to investigate muscle protein synthesis with acute exercise in rats. Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E252-9. Epub 2009 Apr 14.