Directory » JOHN LAWLER
305
862-2038
1997-present Associate Professor,Department of Health and Kinesiology, Texas A&M University
1991-1997 Assistant Professor, Department of Health and Kinesiology, Texas A&M University
1991-1997 Assistant Professor, Department of Health and Kinesiology, Texas A&M University
Education
Ph.D., Exercise Physiology/Medical Physiology, University of Florida (1991)
M.S., Exercise Physiology, Louisiana State University (1987)
B.S., Biomedical Engineering, Duke University (1981)
COURSES TAUGHT
HLTH491. RESEARCH
2016C,2015C
KINE307. LIFESPAN MOTOR DEVELOP
2020C
KINE426. Exercise Biomechanics
2009B,2008C,2008B,2008A,2007C
KINE426. EXERCISE BIOMECHANICS
2020B,2020A,2019C,2019A,2018C
KINE426.
2006A,2005B,2005A,2004B
KINE426. ANALYSIS OF MOVEMENT
2019B
KINE482. SEMINAR IN KINESIOLOGY
2020C
KINE485.
2005B,2005A
KINE485. Directed Studies
2007A,2006C,2006A
KINE485. DIRECTED STUDIES
2017C,2013C
KINE491. RESEARCH
2019C,2019A,2018B,2016C
KINE491. Research
2008B,2007C
KINE627.
2005A
KINE627. Exercise Biomechanics
2008A,2007A,2006A
KINE681. Seminar
2006C
KINE681. SEMINAR
2015A
KINE682. Seminar In
2007C,2006C
KINE682. SEMINAR IN
2020A,2019A,2018A,2017A,2012C
KINE684. Professional Internship
2008A,2007A
KINE685.
2005B,2005A,2004B
KINE685. DIRECTED STUDIES
2020C,2020B,2020A,2019C,2018C
KINE685. Directed Studies
2009A,2008C,2008B,2008A,2007C
FORMER DOCTORAL STUDENTS
Jeffrey Mack Hord (Fall 2016)
Jong Hee Kim (Summer 2009)
Hyo Bum Kwak (Spring 2008)
Wook Song (Fall 2003)
SELECTED PUBLICATIONS
Books and Monographs
Hord, JM, Lawler JM. ROS and nNOS in the Regulation of Disuse-Induced Skeletal Muscle Atrophy. The Plasticity of Skeletal Muscle - From Molecular Mechanism to Clinical Applications. 2016
Lawler, J.M., H.-B. Kwak.: Potential exercise mitigation and regulation of age-induced remodeling in the heart. In "Modern Insights Into Disease: Apoptosis." December, 2009.
Journal Articles
Lawler, JM, Guzzoni V, EE Garcia-Villatoro, JM Hord, JM Kuczmarski, JD Fluckey, S Talcott. Effect of fish oil plus curcumin on skeletal muscle morphology in the C57 mouse. Nutrition Research. doi.org/10.1016/j.nutres.2018.12.013, 2018.
Wu CS, Q. Wei, DM Kim, M Balderas, G Wu, J Lawler, S Safe, S Devaraj, Z Chen, and Y. Sun. Protective effects of ghrelin on fasting-induced muscle atrophy in aging mice. Journal of Gerontology. 2018 Nov 8. doi: 10.1093/gerona/gly256
Guzzoni V, Marqueti RC, Durigan JL, Hernandes LR, Mekaro MS, Costa Santos TO, Mecawi AS, Hord JM, Lawler JM, Davel APC, Selistre-de-Ara[250]jo, HS. Effects of high-intensity resistance training in the extracellular matrix and diastolic function in left ventricle of old male rats. Journal of Applied Physiology. 2017 Jul 6:jap.01090.2016. doi:10.1152.japplphysiol. 01090.2016.
Hord, J., Y. Lee, R. Botchlett, J.H. Kim, JM Lawler. Lifelong exercise and mild caloric restriction against disruption of the dystrophin-glycoprotein complex (DGC) in skeletal muscle. Exp. Gerontology. 2016 Oct; 83:148-57
Lawler JM, D. Rodriguez, and JM Hord. Mitochondria in the Middle: Exercise Preconditioning Protection of Striated Muscle. Journal of Physiology. 594: 5161-5183
Kim, J.H., H.-B. Kwak, and J.M. Lawler. Lifelong wheel running and mild caloric restriction attenuate nuclear Endo-G in rat plantaris muscle. Experimental Gerontology. 69: 122-128, 2015.
Lee, Y., J. Hord, HB Kwak, JH Kim, and JM Lawler. Exercise Training Reduces Age-Dependent Elevation of Angiotensin II Receptor Pathway and TGF-beta in the FBN Rat Heart. Experimental Gerontology. 70:163-73. 2015.
Kwak, H,-B., Y, Lee, and J.-H. Kim, H. Van Remmen, A.G. Richardson and JM Lawler. MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart. J Gerontology: Biological Sciences. 2014 Jul 11. pii: glu090.
Lawler, J.M., M. Kunst, K. Joshi, J. Hord, Y. Lee, R. Botchlett, A. Ramirez, and D.A. Martinez. Regulation of nNOS[181][181] translocation from the sarcolemma and remodeling during short-term mechanical unloading is dependent on oxidative stress in the rat soleus muscle. American Journal of Physiology 306: R470[48]13R482, 2014
Kim, JH, LA Thompson, HB Kwak, JM Lawler. Contribution of oxidative stress to pathology in diaphragm and limb muscles with dystrophin deficiency. Neuromuscular Disorders. 34: 1-13, 2013
Kim, J.-H. and J.M. Lawler. Amplification of pro-inflammatory phenotype, damage, and weakness by oxidative stress in the diaphragm of mdx mice. Free Radical Biology & Medicine. 52: 1597-1606, 2012
Kim, J.H. LA Thompson, HB Kwak, J.M. Lawler. Contribution of oxidative stress to pathology in diaphragm and limb muscles with dystrophin deficiency. Neuromuscular Disorders. 2012
Lawler, J.M. and A. Hindle. Living in a box or call of the wild? Revisiting lifetime inactivity and sarcopenia. Antioxidants & Redox Signaling. May 4 EPub, 2011
Lawler, J.M. Exacerbation of pathology by oxidative stress in respiratory and locomotor muscles with Duchenne muscular dystrophy. Journal of Physiology. 589: 2161-2170, 2011
Lawler, J.M., H.B. Kwak, J.-H. Kim, Y. Lee, and J.M. Hord, and D.A. Martinez. Biphasic stress-response in the rat soleus during reloading following hindlimb unloading. Medicine and Science in Sports & Exercise. Oct 5 EPub, 2011
Murray, I.V.J. and J.M. Lawler. Vascular dysfunction and glucose dyshomeostasis in Alzheimer's disease. Experimental Biology & Medicine. 236: 772-782, 2011
Lawler, J.M., J.-H. Kim, W. Song, S. Demaree, and W.S. Barnes. Redox challenge alters skeletal muscle contractility reversibly: Effect of RyR and DHPR Ca2+ channel antagonists and agonists. Free Radical Biology & Medicine. 49: 1969-1977
Hindle, A.G., Lawler, J.M., Campbell, K.L. and Horning, M. Muscle senescence in short-lived wild mammals, the soricine shrews Blarina brevicauda and Sorex palustris. J. Exp. Zool. 311A, 358-367, 2009.
Hindle, A.G., M. Horning, J.E. Melish, and J.M. Lawler. Diving into old age: muscular senescence in a large-bodied, long-lived mammal, the Weddell seal (Leptonychotes weddellii). Journal of Experimental Biology. 212: 790-796, 2009.
Lawler, J.M., H.-B. Kwak, J.-H. Kim, and M-H Suk. Exercise training upregulates MnSOD while reducing pro-oxidant signaling in the aging rat left ventricle. Am. J. Physiol. 296: R1496-R1502, 2009
Song, W., H.-B. Kwak, and J.M. Lawler : Exercise training modulates the NOS profile in skeletal muscle from old rats. Journal of Gerontology Ser. A Biological Sciences and Med Sciences. 64: 540-549, 2009.
Kim, J.H., H.B. Kwak, C. Leeuwenburgh, and J.M. Lawler. Lifelong exercise and mild (8%) caloric restriction conserve cell morphology of the plantaris in the aging Fischer-344 rat. Experimental Gerontology. In Press. (April 2008).
Marzetti, M, (1)J.M. Lawler, A. Hiona, T. Manini, A.Y. Seo and C. Leeuwenburgh. Modulation of Age-induced Apoptotic Signaling and Cellular Remodeling by Exercise and Caloric Restriction in Skeletal Muscle. Free Radical Biology & Medicine. In Press, published online May 31, 2007.
Kwak, H.-B., W. Song,, and J.M. Lawler. Exercise-training ameliorates age-induced elevation in Bax/Bcl-2 ratio, apoptosis, and remodeling in the aging rat heart. The FASEB Journal. DOI: 10.1096/fj.05-5116fje. Published online February 3, 2006.
Lawler, J.M., H.-B. Kwak, W. Song, and J. Parker. Exercise Training Reverses Downregulation of HSP70 and Antioxidant Enzymes in Porcine Skeletal Muscle after Chronic Coronary Artery Occlusion. American Journal of Physiology. doi:10.1152/ajpregu.00271.2006. Published online July 27, 2006.
Lawler, J.M., Song, W., & Kwak, H.B. Differential regulation of heat shock proteins by hindlimb unloading and reloading in the rat soleus. Muscle and Nerve. 33:200-207, 2006.
Song, W., Kwak, H.B., & Lawler, J.M.(2006). Exercise training attenuates age-induced changes in appropriate signaling in rat skeletal muscle. Antioxidants and Redox Signaling, 8: 517-528.
Lawler, J.M., Song, W., & Demaree, S.R. (2003). Hindlimb unloading increases oxidative stress and disrupts antioxidant capacity in skeletal muscle. Free Radical Biology & Medicine. 35: 9-16.
Lawler, J., Barnes, W., Wu, G., Song, W., & Demaree, S. (2002). Direct antioxidant properties of creatine. Biochemical and Biophysical Research Communications 290, 47-52.
Lawler, J.M. and W. Song. (2002). Specificity of Antioxidant Enzyme Inhibition in Skeletal Muscle to Reactive Nitrogen Species Donors. Biochemical and Biophysical Research Communications. 294, 1093-1100.
Lawler, J.M., Hu, Z., Green, J.S., Crouse, S.F., Grandjean, P.W., & Bounds, R.G. (2002). Combination of estrogen replacement and exercise protects against HDL oxidation in post-menopausal women. International Journal of Sports Medicine, 23:477-483.
Lawler, J.M., Song, W. & Parker J.L. (2002). Is skeletal muscle TNF-lower in pigs with chronic coronary occlusion following exercise training? Medicine and Science in Sports and Exercise. 34, S188.
Song, W., Spier, S.A., Muller-Delp, J. & Lawler, J.M. (2002). Effects of aging and exercise training on iNOS protein expression in skeletal muscle. Medicine and Science in Sports and Exercise. 34, S189.
Lawler, J.M., and Hu, Z., (2000). Interaction of nitric oxide and reactive oxygen species on contractility of the rat diaphragm. Acta Physiologica Scandinavica. 169: 229-236.
O'Kroy, J.A., J.M. Lawler, J. Stone, and T.G. Babb. (2000). Airflow limitation and regulation of end expiratory lung volume during exercise. Respiration Physiology. 119, 57-68.
Demaree, S.R., J.M. Lawler, J. Linehan, and M.D. Delp. Ageing alters aortic antioxidant enzyme activities in Fischer-344 rats. Acta Physiol. Scand. 166: 203-208, 1999.
Gonzalez, J., J.R. Coast, J.M. Lawler, and H.G. Welch. Chest wall restriction to study effects on pulmonary function and exercise. II. The energetics of restrictive breathing. Respiration. 66: 188-194, 1999.
Craig, B.N., J.J. Congleton, C.J. Kerk, J.M. Lawler, and K.P. McSweeney. Correlation of injury occurrence data with estimated maximal aerobic capacity and body composition in a high frequency manual handling tasks. American Industrial Hygeine Association.
Lawler, J.M. and S.K. Powers. Oxidative stress, antioxidant capacity, and the contracting diaphragm. Canadian Journal of Applied Physiology. 23: 23-55, 1998.
Lawler, J.M., Z. Hu, and W.S. Barnes. (1998). Effect of reactive oxygen species on K+contractures in the rat diaphragm. Journal of Applied Physiology. 84: 948-953.
Book Chapters
Botchlett, R, JM Lawler, and G Wu. Arginine and citrulline in sports nutrition and health. In Nutrition and Enhanced Sports Performance: Recommendations for Muscle Building D. Bagchi, S. Nair, and CK Sen (Eds) pp 439-446, 2013
Hindle, A.G., Lawler, J.M., Campbell, K.L., and M. Horning. Muscle aging and oxidative stress in wild-caught shrews. Comparative Biochemistry & Physiology, Part B, 155: 427-434, 2010.
Lawler, J.M. Exercise protection against oxidative stress, apoptosis, and remodeling in aging skeletal muscle. Chapter In: Free Radicals in Biology and Medicine. C. Guti[233]rrez-Merino and C. Leeuwenburgh (Eds.), pp. 1-19, 2008.
Powers, S.K. and J.M. Lawler. Fundamentals of exercise metabolism. In: American College of Sports Medicine Resource Manual for Guidelines for Exercise Testing and Prescription. 3rd Ed. Williams & Wilkins: Baltimore MD, 1998, pp. 129-136.
Powers, S.K., J.M. Lawler, and H.K. Vincent. The diaphragm and oxidative stress. In: Exercise and Oxidative Stress. 1998.
RESEARCH PROJECTS
Targeted Stress Response and Antioxidant Interventions to Mitigate and Promote Recovery
Targeted Stress Response and Antioxidant Interventions to Mitigate and Promote Recovery of Skeletal Muscle and Bone During Extreme Disuse
Targeted Stress Response and Antioxidant Interventions to Mitigate and Promote Recovery of Skeletal Muscle and Bone During Extreme Disuse
Upstream Regulation of Nox2 and Skeletal Muscle Atrophy During Microgravity and Countermeasure Development
Upstream Regulation of Nox2 and Skeletal Muscle Atrophy During Microgravity and Countermeasure Development
Targeted Antioxidant Medical Countermeasures to Mitigate Mixed Radiation-induced Risk of CVD Pathology, Breast Cancer, and Neuropathology in Astronaut-age Rodents
Cyclophilin A and Acid Sphingomyelinase as Novel Regulators of Nox2 Assembly in the Dystrophic Heart
Novel Regulators in Assembly of Nox2 in the Dystrophic Diaphragm
Catapult Round 4 - Novel Approaches to Combatting Disuse Skeletal Muscle Atrophy: Breakthroughs in Mechano- and Nutrient-sensing ($30,000)
Upstream Regulation of Nox2 and Skeletal Muscle Atrophy During Microgravity and Countermeasure Development
Preserving Skeletal Muscle Morphology in Ground-based Microgravity with FDA Approved Interventions: Targeting OxidativeStress, Astronaut Age, and Synergism with Exercise
Nox2 Disrupts nNOS[181] in the mdx Mouse Heart and Diaphragm
Nox2 Regulation of nNOS[181] in the mdx Mouse Heart
Nox2 Disrupts nNOS[181] in the mdx Mouse Heart
Attenuation of Space Radiation-induced Pro oxidant and Fibrotic Signaling in the Heart by Nutritional and Genetic Interventions: Adventures in Tissue Sharing
Nox2 Disrupts nNOS[181] in the mdx Mouse Heart
Failure of nNOS[181] Mechanotransduction and Sarcopenia: Chronic Physical Inactivity and Aging
Nox2 Regulation of nNOS[181] in the Dystrophin-Deficient Heart
Role of Sarcolemma Repair Proteins during Simulated Microgravity in Skeletal Muscle (Student - Jeff Hord)
PESCA: Nox2 Regulation in the Diaphragm Muscle with Duchenne Muscular Dystrophy
Nox2 Regulation in Disuse-induced Skeletal Muscle Atrophy
Exercise Attenuates Fibrosis in the Aging Heart: Regulation of TGF-[223]
Developing Novel, Targeted Countermeasures to Reduce Oxidative Stress and Skeletal Muscle Atrophy During Microgravity (Post-Doctoral Fellowship James Kuczmarksi)
Iron Overload and Oxidative Damage: Regulators of Bone Homeostasis in the Space Environment
Redox Regulation of nNOS Translocation and Muscle Atrophy During Mechanical Unloading
Triggers of Skeletal Muscle NADPH Oxidase During Disuse
Regulation of nNOS[181] Localization and DMD Pathology By Oxidant Pathways in Diaphragm Muscle
Exercise Attenuates Fibrosis in the Aging Heart: Regulation of TGF-[223]
Antioxidant Protection Against Damage, Inflamation, Weakness in the Diaphragm and Locomotor Muscles of mdx Mice
Skeletal Muscle Atrophy During Mechanical Unloading as a Unique "Muscular Dystrophy": Altering the Subsarcolemmal Microenvironment
Redox Regulation of Pathology in the mdx Diaphragm
NAD(P)H Oxidase is Causal in Damage, Inflammation, and Weakness in the Diaphragm of mdx Mice
Optimizing Stress Response by Combining Targeted Nutraceuticals and Exercise Training: Translational Approach to Attenuating Muscle Proteolysis, Atrophy, and Weakness
Redox Regulation of Pathology in the mdx Diaphragm
The Biology of Unloaded Skeletal Muscle as a Form of Muscular Dystrophy: A Paradigm Shift in the Physiology of Muscle Atrophy
Antioxidant Protection Against Damage, Inflammation, Weakness in the mdx Diaphragm
The Biology of Aging Akeletal Muscle as a Form of Muscular Dystrophy: Molecular and Integrative Regulation of nNox by Oxidattive Stress and the Dystroglycan Complex
Exercise Mitigation and Regulation of Age-induced Remodeling in the Heart
Chronic Physical Inactivity Exacerbates Oxidative Stress in Aging Skeletal Muscle
Regulation of MnSOD by Exercise Attenuates Remodeling and Apoptosis in the Aging
Statins, Dietary Cholesterol, and Resistance Exercise Training: Skeletal Muscle Hypertrophy
Exercise Regulation of Apoptosis in the Aging Heart
Statins, Cholesterol, and Exercise: Skeletal Muscle Hypertrophy versus Myopathy
Statins, Dietary Cholesterol, and Resistance Exercise Training: Skeletal Muscle Hypertrophy
Statins, Dietary Cholesterol, and Resistance Exercise Training: Skeletal Muscle Hypertrophy versus Myopathy
Regulation of Oxidative Stress by NAD(P)H Oxidase and HSP70 in the DMD Diaphragm
Exercise Regulation of Apoptosis in the Aging Heart
Molecular Mechanisms of Exercise protection Against Bcl-2 Pathway Apoptosis in the Aging Heart
Regulation of Oxidative Stress in the mdx Diaphragm
Aging in Weddell Seals: Proximate Mechanisms of Age-related Changes in Adaptations to Breath-Hold Hunting in Extreme Environments
Regulation of Oxidative Stres by Nad(P)H Oxidase and HSP70 in the MDX Diaphragm
Regular Exercise Protects the Aging Heart Against Cell Loss and Apoptotic Signaling Through BCL-2 and Cytokine/Fas Pathways
Exercise Protects Against Cytokine Apoptosis in the Aging Heart
Exercise Protects Aging Heart Against BCL-2 Family Apoptosis
Exercise Training Protects Against Pro-Apoptotic Signaling in the Aging Heart
Collaborative Research: Aging in Weddell Seals: Proximate Mechanisms of Age-Related Changes in Adaptations to Breath Hold Hunting in an Extreme Environment
Dysfunction of Stress Proteins Regulates Muscle Atrophy and Susceptibility to Damage with Hindlimb Unloading Via Oxidation
Regulation of Apoptosis in the Dystrophic Diaphragm
Apoptotic Signaling in the Diaphragm and Fast-Twitch Muscle of MDX
Proteomics, Exercise, Aging Heart and Skeletal Muscle
A Graduate Education Program Focusing on Space Life Sciences
Exercise, HSP's, Skeletal Muscle and Heart Ischemia
Exercise Training Protects Against Pro-Apoptotic Signaling in the Aging Heart
Pro-Oxidant Signaling, Aging and Skeletal Muscle
Aging, Exercise Training, and Inos in Skeletal Muscle
Oxidative Stress and Inflammatory Cell Signaling in the Diaphragm and Limb Muscles
Effects of Exercise Training on Age-Induced Upregulation of the Inos Cell Signaling Pathway in Skeletal Muscle
Exercise Training Reverses Age-Induced iNOS Upregulation
Oxidative Stress, Skeletal Muscle & Hindlimb Suspension
The Physiological Basis for Countermeasures Against Oxidative Stress and Skeletal Muscle Wasting with Hindlimb Suspension
Exercise Training-Induced Upregulation of Porcine Skeletal Muscle and Heart Antioxidant Proteins Following Coronary Occulsion
AWARDS
Recognition award. American Physiological Society- Wook Song is student. (2003)
Scholarships for research in the biology of aging. Wook Song - student. (2003)
LEADERSHIP POSITIONS
Advisory Council. American College of Sports Medicine Research. (2005)
Fellow. American College of Sports Medicine. (2000)
Graduate Assessment Officer - Exercise Science. Exercise Science. (2012)
Young Investor Award. Rachel Botchlett. (2013)